Browsing by Author "Carvalho, A"
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- Anti-Signal Recognition Particle Myopathy in a Geriatric PatientPublication . Ferreira, DM; Mendes, PA; Aragão, A; Veríssimo, T; Carvalho, AAnti-signal recognition particle (SRP) myopathy is a rare idiopathic inflammatory myositis that usually affects middle-age women, and is characterized by rapidly progressive proximal and symmetrical muscle weakness, elevated creatine kinase levels, severe necrotizing immune-mediated myopathy, presence of anti-SRP autoantibodies and poor response to steroid therapy. We report a geriatric case of a previously independent patient, presenting with slow onset of proximal paraparesis, myalgia and severe gait impairment. The patient was treated with steroid and azathioprine, with laboratory and pain response but modest muscle strength improvement. The clinical presentation of this unusual patient was atypical, which hampered the correct diagnosis.
- Doença associada ao Clostridium difficile – aumento dramático da incidência em doentes internadosPublication . Correia, L; Monteiro, R; Alfaro, TM; Simão, A; Carvalho, A; Nascimento-Costa, JMMany publications show an incidence increase of Clostridium difficile (CD) associated disease (CDAD), affecting both in- and outpatients being these recent infections more severe and difficult to treat. The aim of this retrospective study is to evaluate the incidence and clinical impact of CDAD in patients hospitalized from the 1st January 2004 to the 31st December 2009. Suggestive clinical manifestations and at least one of the following were the inclusion criteria: CDAD compatible colonoscopy or CD positive toxin. We identified 83 cases of CDAD (32M, 51W), in a total of 9581 patients (5198M, 4383W). Age ranging from 47 to 94 years (average 79). Five patients had CDAD acquired in the community and 78 in hospital environment. The incidence of CDAD increased almost six fold between 2004 and 2009 (4.35/1000 vs. 21.63/1000), and 77.11% developed the disease during hospitalization. The disease was more frequent in women (11.64/1000 vs. 6.16/1000). All patients had undergone prior antibiotherapy. The comorbidities, number of antibiotics used, advanced age, duration of the antibiotherapy and the length of hospitalization did not seem to justify the increase in incidence and severity. In 96% the diagnosis was confirmed by the presence of Clostridium toxin and in 4% by colonoscopy. Seventy three patients (88%) were treated with metronidazole and 30% died (the department overall mortality was 13%). Probably, it was the advanced age related with the worst severity scenario which caused the high mortality in our cases.
- Doença de Hodgkin apresentando-se como síndrome febril indeterminadoPublication . Branco, V; Salvador, MJ; Silva, MR; Martins, P; Carvalho, A; Almiro, E; Porto, A
- Estimation of the collective ionizing dose in the Portuguese population for the years 2011 and 2012, due to nuclear medicine examsPublication . Costa, F; Teles, P; Nogueira, A; Barreto, A; Santos, A I; Carvalho, A; Martins, B; Oliveira, C; Gaspar, C; Barros, C; Neves, D; Costa, D; Rodrigues, E; Godinho, F; Alves, F; Cardoso, G; Cantinho, G; Conde, I; Vale, J; Santos, J; Isidoro, J; Pereira, J; Salgado, L; Rézio, M; Vieira, M; Simãozinho, P; Almeida, P; Castro, R; Parafita, R; Pintão, S; Lúcio, T; Reis, T; Vaz, PIn 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation doses for the Portuguese population. The current study is the continuation of this work, although it focuses only on NM exams for the years 2011 and 2012.
- Febre escaro-nodular: uma zoonose benigna?Publication . Louro, E; Campos, A; Leitão, J; Carvalho, A; Santos, R; Reis, C; Almiro, E; Porto, A
- First report of chronic hepatitis E in renal transplant recipients in PortugalPublication . Breda, F; Cochicho, J; Mesquita, JR; Bento, A; Oliveira, RP; Louro, E; Nascimento, MS; Leitão, J; Gomes, HV; Carvalho, AHepatitis E virus (HEV) infection can be responsible for chronic hepatitis in immunocompromised patients, and can rapidly evolve into fibrosis and/or hepatic cirrhosis. We present two cases of chronic hepatitis E, emphasizing the need to be aware of this entity as a growing etiology of hepatitis in transplant and immunocompromised patients.
- Genótipos do VHC: Histopatologia hepática e perfil imunológico em quatro grupos de doentesPublication . Carvalho, A; Martinho, A; Leitão, J; Cipriano, MA; Coimbra, H; Porto, AAIM: Study on the prevalence of MCV genotypes, and correlation with liver pathology and immunological parameters. PATIENTS AND METHODS: 77 chronic hepatitis C patients (52 males, 25 females), mean age 44 +/- 14 years, belonging to four groups: (1) 23 (11 males) without other aetiology, (II) 19 (18 males) excessive drinkers, (III) 18 (12 males) haemodialysed, (IV) 17 (11 males) renal transplantation patients Genotyping was done by PCR (primers of the core, and hybridisation with specific probes). Serum Igs A, G, and M (by nephelometry), and peripheral blood lymphocyte (PBL) subsets (by flow cytometry) were determined. RESULTS: One genotype was found in 62 patients (1b 69.2%, 1a 21.5%, 2a 3.1%, 2b 3.1%, 3a 9.2%), and two genotypes in 4 patients (1b + 3a in 1 of group 1, 1b + 2a in 2 and 1a + 3a in 1 of group 111). Twelve cases (15.6%) were not identified (NI). Relative prevalence was not different in the four groups, but in 7 drug addicts 1 b was not found (Ia in 71.4%, 3 a 28.6%) The relationship between genotypes and age was significant (p < 0.05): in the 34 patients with less than 40 years, 1b was found in 38.2%, in the others in 41.2%, and NI in 20.6%; in those with 40-60 years, 1b was found in 68.8%, in the others in 15.6%, M in 15.6%; in those above 60 years, 1b was found in 90.9%, in the others in 9.1%. Of those identified, only genotype 1 (1a and 1b) was associated to moderate or severe activity, and infected 11/13 cases of cirrhosis or severe fibrosis. IgM (g/dL) was lower in 1b than in the others: 1.58 + 1.23 vs. 2.53 + 1.93 (p < 0.01). PBL (per mm3) were lesser in 1b than in the others, with significance for the CD8+: 540t239 vs. 739 + 420 (p < 0.01). CONCLUSIONS: Genotype 1b was the most prevalent in Portuguese patients, more significantly in the elderly, and was absent in drug addicts. The prevalence of genotypes is similar in general patients, in chronic haemodialysed, in renal transplantation recipients and in alcoholics. More severe liver pathology was associated with 1b and 1a genotypes. IgM and CD8+ had lower mean values in 1b infected patients. Other genotypes are certainly important in Portugal.
- Hemotórax espontâneo como forma de apresentação de síndrome de Ehlers-DanlosPublication . Couto, M; Ambrósio, C; Bettencourt, J; Leitão, J; Presa, J; Carvalho, A; Porto, A
- Hepatite Autoimune: casuística de um serviço de Medicina InternaPublication . Vaio, T; Ferreira, P; Santos, A; Simão, A; Perdigoto, R; Santos, R; Carvalho, A; Porto, A
- Hypertriglyceridemic Pancreatitis: Conventional Treatment Versus Therapeutic Plasma ExchangePublication . Ferreira, DM; Lobo, F; Fonseca, JP; Mendes, PA; Aragão, A; Ferreira, M; Tomáz, J; Ferreira, M; Carvalho, AIntroduction: Acute pancreatitis (AP) induced by hypertriglyceridemia (HTG) can be treated with therapeutic plasma exchange (TPE), resulting in rapid reduction of triglyceride level. However, there are no definitive comparative studies that prove the real benefits of this therapy. Objectives: Comparison of treatment methods (TPE versus conventional) in patients with HTG AP during a period of 12 years (2000-2012). Methods: Retrospective, descriptive and inferential analysis of 37 patients, evaluating: gender, age, personal pathologic history, severity of disease, HTG values and evolution depending on treatment with therapeutic plasma exchange (“TPE”) or with conventional therapy (“C”). Results: Both groups TPE and C demonstrated homogeneity considering gender (p = 0.647), age (43.5 ± 9.74 years TPE vs 45.30 ± 9.90 years C; p = 0.320), prior AP episode (40% TPE vs 40.7% C; p = 1.0), chronic alcohol consumption (50% TPE vs 70.4% C; p = 0.275) and severity disease scores: APACHE II (p = 0.054) and Ranson (p = 0.258). More than one secondary HTG risk factor was presented in 45.95% of patients . TPE group presented higher TG levels at admission: 4850 ± 2802 mg/dL vs 1845 ± 1858 mg/dL (p = 0.001). No significant statistical differences were observed considering length of hospital stay [14.2 ± 6.8 days vs 13.5 ± 9.0 days (p = 0.56)] or mortality rate (p = 0.47). At discharge, TG reduction was greater in TPE group: 4433.70 ± 2896.08 mg/dL – 91.41% vs 1582.95 ± 2051.06 mg/dL – 83,92% (p = 0.002). Six minor complications associated to TPE occurred. Discussion/Conclusion: Despite the selection bias (retrospective study), a greater TG reduction was observed with TPE technique. Complications associated with the technique were simple to resolve
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