Browsing by Issue Date, starting with "2000"
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- Osteoporose na Doença Inflamatória IntestinalPublication . Lérias, C; Portela, F; Pereira da Silva, JA
- A vulnerabilidade ao stressPublication . Vaz-Serra, A
- Lesões do colo uterino e infecção pelo vírus do papiloma humano (HPV) detecção e tipificação do ADN/HPV por PCR (reacção de amplificação enzimática)Publication . Serra, H; Pista, A; Figueiredo, P; Urbano, A; Avilez, F; Oliveira, CFThe prevalence of human papillomavirus (HPV) genotypes was estimated by the polymerase chain reaction (PCR), in archival paraffin was embedded tissues. The case group consisted of 84 women aged 21-67 years (mean, 40 years) who were referred to the Department of Gynaecology (Oncology Centre, Coimbra) with citopathologically abnormal smears. This group was selected from a population of women who had undergone a screening programme (1990/94) in Central Region of Portugal. All these patients (n = 84) had a colposcopic directed cervical biopsy. HPV detection and typing was performed by the PCR method in the Department of Virology (National Health Care Institute, Lisbon). The prevalence of DNA/HPV found, concerning all epithelial cervical lesions studied and classified as squamous intra-epithelial lesions (SIL) and cervical cancer was 97.8%. On the basis of the data presented in this study, it was estimated that there was a statistically significant prevalence of low risk HPV types (HPV 6/11) in low grade SIL, 83.3%, and a statistically significant prevalence of high risk HPV types (HPV 16,18,31,33,51) in high grade SIL, 58.4%, as well as cervical cancer lesions in 100%. We conclude that there was a statistically significant difference between women with low and high grade SIL for HPV infection, with low and high risk HPV types, respectively. The risk factors for cervical cancer investigated (age at first sexual intercourse, multiple sexual partners, parity, use of oral contraceptives) were not associated to statistically significant differences concerning low grade SIL and high grade SIL. The clinical and therapeutic procedures were evaluated for the same five years (1990/94). It may be concluded that there would be no significant difference in clinical procedure for high grade lesions and cervical cancer, in which the treatment had been frequently radical (cone biopsies, simple or radical hysterectomy) and in which the HPV infection persisted frequently and was associated to high risk types (HPV 16 in 50% of these cases). On the other hand, it may be concluded that HPV detection in cervical biopsies, especially for low grade SIL lesions, which were evaluated in this study with a more conservative procedure (clinical evaluation only, punch biopsies, loop diathermy, CO2 laser vaporisation, cone biopsies), could identify women with high risk HPV types who might be at risk of developing dysplasia and cervical cancer.
- Domino liver transplantation using livers from patients with familial amyloidotic polyneuropathyPublication . Furtado, ALTransplantation of livers from patients with familial amyloidotic polyneuropathy undergoing orthotopic liver transplantation is based on the normal functions of these livers, except for the production of an abnormal protein that causes the disease, which takes more than 20 years to become clinically apparent. Given the shortage of cadaver grafts, domino liver transplantation has the potential to increase the offer to some selected patients. The known experience amounts to little more than 80 cases. Domino liver transplantation has been a safe procedure with all the advantages of living donor grafts. So far, the disease has not shown up in any recipient, including the longest surviving patient (4 years). Particularly in countries where the disease is common, the potential to increase graft offer may be significantly augmented through cooperation between centers and better exploitation of technical possibilities. The combination of split and domino has been reported six times and may provide three to six transplants from only one cadaver graft
- Cintigrafia óssea no diagnóstico de fractura do escafóidePublication . Lapa, P; Ferrer-Antunes, A; Lima, J
- Lobulite linfocítica esclerosante: a propósito de um caso clínicoPublication . Carvalho, G; Silva, T; Sousa, R; Franco, S; Cortesão, P; Oliveira, CF
- Dermatoses professionales por plantas y maderasPublication . Gonçalo, Margarida
- Maculopapular eruption from sertraline with positive patch testsPublication . Fernandes, B; Brites, MM; Gonçalo, Margarida; Figueiredo, A
- Prevalência dos marcadores de infecção pelo vírus da hepatite B na população adulta do distrito de CoimbraPublication . Santos, A; Carvalho, A; Tomaz, J; Rodrigues, V; Coxinho, L; Bento, D; Sá, R; Porto, AAIM: To assess the prevalence of hepatitis B markers in the adult population of the Coimbra district, in the central region of Portugal. METHODS: The study included 657 subjects chosen aleatorily from 4 characteristic councils of the Coimbra district. They were questioned regarding risk factors and blood samples were taken for HBsAg, anti-HBs and anti-HBc testing. Anti-HCV was previously determined and it was positive in 0.45% of the cases. RESULTS: HBsAg was found in 0.91%. Anti-HBs and anti-HBc were both positive in 6.08%, anti-HBc without anti-HBs was found in 1.82% and anti-HBs without anti-HBc was found in 1.67% (11 cases, 8 vaccinated). The general prevalence of hepatitis B markers was 9.3%. Higher prevalences were found in the subjects over 50 years of age, 13.5% (p < 0.05), and in the urban area, 13.2% (p < 0.05). CONCLUSIONS: 1. The HBsAg prevalence in our region is 0.9%; 2. The general prevalence of hepatitis B markers is 9.3%; 3. HBsAg prevalence is higher than anti-HCV prevalence calculated in the same sample; 4. The prevalence of hepatitis B markers in our region is lower than in other Southern European countries.