REU - Artigos
Permanent URI for this collection
Browse
Browsing REU - Artigos by Issue Date
Now showing 1 - 10 of 116
Results Per Page
Sort Options
- Hormonas sexuais e osteoporose: a perspectiva fisiológica da prevenção e terapêuticaPublication . Pereira da Silva, JA; Porto, AEstrogen deficiency is the main cause of post-menopausal osteoporosis and hormone replacement therapy is consensually regarded as the first line choice for its prevention. Hormone-replacement has also been shown to prevent bone loss associated with rheumatoid arthritis (RA) and corticotherapy. The rationale for its use in RA is reinforced by evidence of beneficial effects on disease activity. Estrogens also have bone-protective effects in males. C-19 progestagens seem to potentiate the skeletal effects of estrogens whereas C-21 derivatives appear to have no significant influence. Progestagens may be particularly useful in the prevention of steroid-induced osteopenia. Testosterone is an effective treatment for male osteoporosis associated with hypogonadism and is also promising in the treatment of osteoporosis in aged eugonadal males. The association of this hormone potentiates the effects of estrogens on bone mineral density in post-menopausal women. However, anabolic androgens have been preferred in this condition, due to a lower androgenizing effect. They represent a valid therapeutic alternative, particularly in cases of cortical osteoporosis with low bone turnover and in the aged and frail. In general, the different modalities of hormonal therapy clearly deserve a higher degree of preference in the treatment and prevention of osteoporosis than common present practice in our country. It is time to reassess this matter, clear unfounded fears and reinforce the physiological and scientific foundations of our therapeutic options for osteoporosis.
- Apontamentos sobre a história da Reumatologia na Zona CentroPublication . Moura, JJ; Porto, A
- Osteoporose na Doença Inflamatória IntestinalPublication . Lérias, C; Portela, F; Pereira da Silva, JA
- Termalismo nas Doenças Reumáticas: Panaceia ou Placebo?Publication . Alexandre, M; Malcata, AB
- Arthropathy of genetic hemochromatosis: a major and distinctive manifestation of the diseasePublication . Inês, L; Pereira da Silva, JA; Malcata, ABGenetic hemochromatosis is not a rare disease and represents a frequently underestimated cause of arthropathy. Joint involvement is one of the most frequent manifestations of the disease and presents typical clinical and radiological features that strongly suggest the diagnosis. Joint complaints are often the first clinical manifestation of GH. Their identification may be crucial to establish the diagnosis in the pre-cirrhotic phase and to institute appropriate therapy to prevent organ damage and associated mortality. Recent identification of the genetic defect responsible for the disease is leading to new insights into the pathogenesis of GH and the associated arthropathy.
- Artropatia dos joelhos como manifestação inicial de neoplasia pulmonarPublication . Inês, L; Santos, MJ; Silva, C; Braña, A; Nour, D; Reis, P; Malcata, AB; Porto, AApresentamos o caso de uma doente de 46 anos que recorreu ao serviço de urgência por dor e tumefacção dos joelhos com 3 meses de evolução. Na subsequente observação em Reumatologia identificou--se a presença de baqueteamento digital nas mãos e pés (com cerca de 1 ano de evolução) e edema dos membros inferiores. As radiografias dos ossos longos demonstraram a presença de periostose. A investigação de causas de osteoartropatia hipertrófica secundária revelou a existência de uma neoplasia pulmonar volumosa, que não apresentou no exame clínico quaisquer manifestações respiratórias.
- Differential male and female adrenal cortical steroid hormone and cortisol responses to interleukin-6 in humansPublication . Silva, C; Inês, L; Nour, D; Straub, RH; Pereira da Silva, JAEvidence from experimental animal studies show that sex hormones influence the glucocorticoid response to a variety of inflammatory and noninflammatory stimuli. In this study we assessed gender differences in the response of ACTH and cortisol in normal young male and female humans following intravenous infusion of human IL-6 in various dosages. Males presented a significantly stronger ACTH production in response to IL-6 than females. Peak cortisol response, however, was similar in males and females. Cortisol/ACTH ratios were significantly higher in females than in males, both at baseline and after each of the IL-6 dosages. These results suggest that an effective glucocorticoid response requires similar levels of IL-6 in males and females. However, they also suggest that the adrenals of males and females have different sensitivities to ACTH (higher in females) and possibly also to direct IL-6 stimulation.
- Radiografia das mãos: elementos típicos em artropatias comunsPublication . Barcelos, A; Nour, D; Pereira da Silva, JA
- Um Caso de Dor Contínua em Mulher JovemPublication . Barcelos, A; Silva, C; Reis, P; Malcata, AB; Porto, A
- Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritisPublication . Pereira da Silva, JAGender and sex hormones are strongly related to the incidence and progression of autoimmune rheumatic diseases. Although sex steroids have been shown to have direct effects on the immune system, their influence in vivo may be mediated via interactions with third party systems including the hypothalamic-pituitary-adrenal axis. Such interactions are well demonstrated in experimental animals. In humans, there is increasing, although indirect, evidence that these interactions also occur. Possible interactions at the cell and gene level, with mutual antagonism or synergy between cortico- and gonadal steroids, open new exciting hypotheses that await clarification.