Nefrologia
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- Determinação da clearance do 99mTcDTPA por registo externo e por contagem da actividade sanguíneaPublication . Pedroso de Lima, J; Branco, JR; Campos, M; Ferreira, CM; Gondar, MM; Cravinho, MP; Ruas, MC; Ferrer-Antunes, A; Lima, J; Sousa, JP; Martins, RC; Marques, A
- Amiloidose ß2 - microglobulina numa população de insuficientes renais crónicos em hemodiálise regularPublication . Grade, MJ; Nabais, MJ; Ramos, F; Negrão, L; Cabrita, A; Ralha, E; Alexandrino, MB; Serra e Silva, P
- Transplantação renal em doentes com diabetes mellitus tipo I e tipo IIPublication . Baptista, C; Bastos, M; Gomes, L; Macário, F; Ruas, L; Rodrigues, D; Alves, R; Gomes, H; Ferreira, C; Roseiro, A; Paiva, S; Barros, L; Carvalheiro, M; Mota, A; Furtado, AL; Ruas, AA total of 618 patients with end-stage renal disease received kidney transplants between 1980 and September 1996. Twenty eight of them were diabetics. Better results were achieved for type 1 diabetic patients than for type 2 (mortality: 5.9% vs 27.3%; functioning graft: 88.2% vs 72.7%). The morbility was also higher in those patients (infections: 81.8% vs 29.4%; vascular complications: 45.5% vs 17.6%). Actuarial patient and graft survival were lower for type 2 than for non diabetic patients. For type 1 diabetics the results are similar to those for non diabetics. Better results can probably be achieved by restricting the selection criteria. The decision to transplant or maintain on dialysis should be made on a case by case basis.
- Nefropatia diabética: protocolo de estudo pré-transplantação renalPublication . Baptista, C; Bastos, M; Paiva, S; Martins, T; Leitão, P; Lemos, MC; Alves, R; Bastos, C; Mota, A; Carvalheiro, M; Furtado, AL; Ruas, ABetween May 1990 and October 1998, 67 diabetic patients with end-stage renal disease, on dialysis, were submitted to a standardized protocol in order to assess the coexistence and degree of other diabetic and nondiabetic complications that could affect transplantation. Some of the results were analysed. Type 2 diabetic patients had more abnormal results on the lower limbs doppler ultrasound and on the lower limbs arteriography than type 1 (p < 0.05). Type 2 diabetic patients had more cardiovascular complications so the decision to transplant should be taken on a case by case basis.
- Kidney transplantation and posttransplantation diabetes: nutritional evaluationPublication . Loureiro, H; Silva, RS; Machado, C; Bastos, M; Baptista, C; Alves, R; Mota, A; Furtado, AL; Carvalheiro, M; Saldanha, MH
- Kidney transplantation and diabetes: posttransplantation malignancyPublication . Bastos, M; Baptista, C; Campos, MV; Alves, R; Freitas, L; Bastos, C; Leitão, P; Lemos, MC; Mota, A; Furtado, AL; Carvalheiro, M
- Tacrolimus Versus Cyclosporine: a study about two immunosuppressive regimensPublication . Lemos, S; Macário, F; Pratas, J; Figueiredo, A; Bastos, C; Mota, A; Campos, M
- Transplantação pancreáticaPublication . Bastos, M; Campos, MV; Baptista, C; Alves, R; Bastos, C; Mota, A; Carvalheiro, M; Furtado, AL; Ruas, AA clinic case of simultaneous pancreas/kidney transplantation on a type 1 diabetic patient is described. A six years follow-up was made with both organs functionating and a good quality of live.Then the authors make a review of the available surgical techniques, indications and complications of this form of treatment. A comparison between the Portuguese and the International experience was discussed.
- Miocardite Lúpica: a propósito de um caso clínicoPublication . Costa, S; Franco, F; Monteiro, P; Oliveira, L; Vieira, H; Garrido, L; Gonçalves, L; Gomes, H; Campos, M; Providência, LAMyocarditis is one of the many possible forms of cardiac involvement in systemic lupus erythematosus. Its clinical presentation ranges from asymptomatic patients with self-limited disease to fulminant heart failure that can lead to death. In most cases treatment consists of supportive care only. The authors present the case of a patient with lupus myocarditis.
- Calcineurin inhibitor-free immunosuppression in renal transplantationPublication . Parada, B; Mota, A; Nunes, P; Macário, F; Pratas, J; Bastos, C; Figueiredo, APURPOSE: To describe our initial results using a calcineurin inhibitor-free immunosuppression protocol in renal transplants. PATIENTS AND METHODS: Between October 2001 and June 2003, 56 recipients of a renal allografts were started on an immunosuppression protocol without calcineurin inhibitors, consisting of basiliximab, sirolimus, mycophenolate mofetil, and steroids. We analyzed patient and graft survival, acute rejection episodes, and renal function. RESULTS: The mean follow-up was 19.6 months. Actuarial patient survival at 1 and 2 years was 98.1% and 95.3%, respectively. Actuarial graft survival at 1 and 2 years was 92.9% and 87.6%, respectively. Acute rejection occurred in 27.8% of the patients, usually Banff 1 (73.3%). There was stable renal function with mean serum creatinine of 1.3, 1.4, 1.3, and 1.3 mg/dL at 1, 6, 12, and 24 months after transplant. CONCLUSIONS: The use of immunosuppression free of calcineurin inhibitors is effective and safe. Further follow-up is needed to evaluate the impact on long-term results.