Browsing by Author "Marques, A"
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- Controlo ambiental das áreas de processamento dos aloenxertosPublication . Francisco, C; Marques, A; Dias, R; Judas, FOs Banco de Tecidos Alógenos do Sistema Musculoesquelético devem incluir nos seus procedimentos disposições especiais relativas à manipulação de tecidos por forma a evitar não só a contaminação de outros tecidos como também garantir a qualidade ambiente e a segurança do pessoal de acordo com a Lei 12/2009 de 26 de março alterada pela Lei 1/2015 de 8 de janeiro. Neste âmbito, são descritos diversos procedimentos que incluem: o controlo ambiental das áreas de colheita, processamento e preservação dos tecidos; a utilização de técnica assética cirúrgica na manipulação dos tecidos, controlo da temperatura e humidade; controlos microbiológicos das superfícies e do ar; controlo do ambiente frio para conservação dos aloenxertos; equipamentos com condições particulares de instalação e, ainda, procedimentos sobre a prevenção de contaminações.
- Determinação da clearance do 99mTcDTPA por registo externo e por contagem da actividade sanguíneaPublication . Pedroso de Lima, J; Branco, JR; Campos, M; Ferreira, CM; Gondar, MM; Cravinho, MP; Ruas, MC; Ferrer-Antunes, A; Lima, J; Sousa, JP; Martins, RC; Marques, A
- Doseamento das granzimas A e B na sarcoidose pulmonar (estudo experimental)Publication . Dourado, M; Bento, J; Mesquita, L; Marques, A; Vale-Pereira, S; Ribeiro, AB; Mota-Pinto, ASarcoidosis is a systemic disease of unknown aetiology, morphologically characterized by well-formed epithelioid granulomas, which show little or no central necrosis. These may be present in any organ or tissue. The lung is the most frequently and prominently involved target. The granuloma is often very sharply demarcated from the adjacent tissue and is surrounded by a mantle of lymphocytes, which mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins, perforins and granzymes. Sarcoidosis laboratorial diagnosis is usually made by SACE and Lisozyme dosages. The granzymes A and B could be two other markers of the disease, since the sarcoidosis granuloma is rich in cytotoxic and NK cells. An ELISA Kit was used to measure Granzyme A and B in serum of a normal control group (NC) (n=30), and in two groups with lung pathology: one without sarcoidosis, disease control (DC) (n=21) and other with sarcoidosis (S) (n=11). Our results showed that SACE activity is significantly augmented in S group comparing with NC and DC, respectively: 82,6+/-32,7/31,9+/-17,8 - p=0,00017 and 82,6+/-32,7/31,9+/-17,8 - p=0,00024. Lisozyme activity is significantly augmented in S and DC groups comparing with NC. Granzyme B showed a significant decrease in DC and S groups comparing with NC. Granzyme A showed a significant decrease between S/NC groups. Our results suggest that the decrease of Granzyme A and B in sarcoidotic patients could be related to an ineffective inflammatory local response related to the formation of sarcoidosis granulomas. More studies are needed, particularly in BAL.
- Postanesthetic Severe Oral Angioedema in Patient's Taking Angiotensin-Converting Enzyme InhibitorPublication . Marques, A; Retroz-Marques, C; Mota, S; Cabral, R; Campos, MAngiotensin-converting enzyme (ACE) inhibitors are the leading cause of a drug-induced angioedema. This occurrence is frequently underdiagnosed, but its relapse can be life-threatening. The authors' intention in reporting this clinical case is to sound a warning about reviewing attitudes and surveillance to try to improve patient perioperative safety.
- Rapid progression of a severe femoral bone loss in a stable revision hip prosthesis: causes and managementPublication . Judas, F; Marques, A; Maximino, L; Lucas, F
- The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortalityPublication . Marques, A; Lourenço, Ó; Pereira da Silva, JA; Portuguese Working Group for the Study of the Burden of Hip Fractures in Portugal.The study rationale was to provide a detailed overview of the costs, quality of life and mortality of hip fractures in Portugal. Mean individual fracture-related costs were estimated at 13,434 [12,290; 14,576] for the first year and 5985 [4982; 7045] for the second year following the fracture. INTRODUCTION: Osteoporotic fractures represent a remarkable burden to health care systems and societies worldwide, which will tend to increase as life expectancy expands and lifestyle changes favour osteoporosis. The cost-effectiveness evaluation of intervention strategies demands accurate data on the epidemiological and economical reality to be addressed. METHODS: Information was collected retrospectively on consumption of resources and changes in quality of life attributable to fracture as well as mortality, regarding 186 patients randomly selected to represent the distribution of hip fractures in the Portuguese population, in terms of gender, age and geographical provenience. Data were cross-tabulated with socio-demographic variables and individual resource consumption to estimate the burden of disease. A societal perspective was adopted, including direct and indirect costs. Multivariate analyses were carried out to assess the main determinants of health-related quality of life (HrQoL). RESULTS: Mean individual fracture-related costs were estimated at 13,434 [12,290; 14,576] for the first year and 5985 [4982; 7045] for the second year following the fracture. In 2011 the economic burden attributable to osteoporotic hip fractures in Portugal could be estimated at 216 million. Mean reduction in HrQoL 12 months after fracture was estimated at 0.34. Regression analysis showed that age was associated with a higher loss of HrQoL, whereas education had the opposing effect. We observed 12 % excess mortality in the first year after hip fracture, when compared to the gender and age-matched general population. CONCLUSIONS: Results of this study indicate that osteoporotic hip fractures are, also in Portugal, despite its low incidence of fractures and cost per event, associated with a high societal burden, in terms of costs, loss in HrQoL and mortality. These data provide valuable input to the design and selection of fracture prevention strategies.
- The Portuguese version of the Body Image Scale (BIS): psychometric properties in a sample of breast cancer patientsPublication . Moreira, H; Silva, S; Marques, A; Canavarro, MCPURPOSE: The aim of this study was to analyse the psychometric properties of the Portuguese version of the body image scale (BIS; Hopwood, P., Fletcher, I., Lee, A., Al Ghazal, S., 2001. A body image scale for use with cancer patients. European Journal of Cancer, 37, 189-197). This is a brief and psychometric robust measure of body image for use with cancer patients, independently of age, cancer type, treatment or stage of the disease and it was developed in collaboration with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Study Group. METHOD: The sample is comprised of 173 Portuguese postoperative breast cancer patients that completed a battery of measures that included the BIS and other scales of body image and quality of life, in order to explore its construct validity. RESULTS: The Portuguese version of BIS confirmed the original unidimensional structure and demonstrated adequate internal consistency, both in the global sample (alpha=.93) as in surgical subgroups (mastectomy=.92 and breast-conserving surgery=.93). Evidence for the construct validity was provided through moderate to largely sized correlations between the BIS and other related measures. In further support of its discriminant validity, significant differences in BIS scores were found between women who underwent mastectomy and those who underwent breast-conserving surgery, with the former presenting higher scores. Age and time since diagnosis were not associated with BIS scores. CONCLUSIONS: The Portuguese BIS proved to be a reliable and valid measure of body image concerns in a sample of breast cancer patients, allowing a brief and comprehensive assessment, both on clinical and research settings.