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- Kikuchi's disease associated with Epstein-Barr virus infectionPublication . Rabadão, EM; Oliveira, JF; Saraiva da Cunha, JG; Côrte-Real, R; Meliço-Silvestre, AA
- Dengue myocarditis in Singapore: two case reportsPublication . Marques, N; Gan, VC; Leo, YS
- Global expression of Chagas´ disease - emerging opportunities and impact in PortugalPublication . Cortez, J; Ramos, E; Valente, C; Seixas, J; Vieira, AChagas disease, caused by the protozoan Trypanosoma cruzi is endemic in the countries of Central and South America. Despite vector control programs and other measures taken in the blood banks and maternity hospitals, it is estimated that there are about eight million people infected worldwide. Although traditionally associated with rural life and poverty, the current migration flows transform it into a global public health problem. In Portugal, this problem is poorly known, with an estimated underdiagnosis index that exceeds 99%. In European countries, besides imported cases, autochthonous infections arise through vertical transmission and blood/organ donation.The conventional serological tests for diagnosing Chagas disease and verifying its cure are indirect hemagglutination (IHA), indirect immunofluorescence (IFAT), and enzyme-linked immunoabsorbent assay (ELISA).The hypothesis of autoimmunity as a basic mechanism of this disease and the absence of early markers of cure are the causes of controversy regarding the specific treatment of this disease. The currently available drugs have adverse effects on a large number of patients and parasitological efficacy in chronic disease is suboptimal.The authors reinforce the need of a high level of suspicion in patients with suggestive epidemiology and the need of populational screening of specific high risk groups.
- Emerging and under-recognized Chagas cardiomyopathy in non-endemic countriesPublication . Cortez, J; Providência, R; Ramos, E; Valente, C; Seixas, J; Meruje, M; Leitão-Marques, A; Vieira, ADue to recent population emigration movements, an epidemic of Chagas disease is currently menacing most developed countries. The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms, having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 years. The diagnosis was based on serology and myocardial biopsy and the patient was treated with nifurtimox. The authors emphasize the need of a high level of suspicion in patients with suggestive epidemiology and the need of populational screening of specific high risk groups. New treatment options are also discussed.
- Polineuropatia desmielinizante inflamatória como primeira manisfestação de infecção VIH-1Publication . Speidel, A; Shamasna, M; Velho, P; Coelho, R; Oliveira, F; Faria, MJ; Barros, MS
- Leptospirose: casuística do Serviço de Infecciologia do Centro Hospitalar de Coimbra 1990-2007Publication . Speidel, A; Faísca, R; Fernandes, C; Vieira, AA; Barros, MS; Valente, C; Trindade, L; Faria, MJ; Almeida, H; Correia, L
- Primo-infecção pelo vírus Epstein-Barr: forma menos vulgar de apresentaçãoPublication . Valente, C; Faria, MJ; Trindade, L; Barros, MS; Vieira, AA
- Prevalência do Anticorpo contra o VHA numa população na Região Centro de PortugalPublication . Speidel, A; Malaba, N; Marques, R; Alves, J; Veríssimo, R; Valente, C; Trindade, L; Correia, L
- Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed cerebellar ataxiaPublication . Duque, V; Seixas, D; Ventura, C; Saraiva da Cunha, JG; Meliço-Silvestre, AWe describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery phase. This occurred after successful treatment with quinine plus doxycycline over seven days. Different levels of thrombocytopenia and C-reactive protein were observed during both neurologic events in the presence of HRP-2 positive tests for Plasmodium falciparum antigen. The patient recovered completely after three months.
- First report of acute autochthonous hepatitis E in PortugalPublication . Duque, V; Ventura, C; Seixas, D; Saraiva da Cunha, JG; Meliço-Silvestre, AHepatitis E infection is usually a self-limiting disease. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described; their number seems to be increasing in European countries. We report the first human case of autochthonous acute hepatitis E confirmed in Portugal. Patients with acute non-A-C hepatitis should be tested for HEV in Portugal and hepatitis E infection should be considered in the differential diagnosis of unexplained hepatitis cases.
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