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- Adenocarcinoma do pâncreas localmente avançado e metastizado com resposta completa a quimioterapiaPublication . Freire, P; Coelho, AJ; Rodrigues, A; Silva, MR; Lapa, P; Graça, B; Porto, AOs autores apresentam o caso clínico de doente do sexo feminino, 54 anos, raça branca, que recorreu ao médico assistente por dor abdominal associada a manifestações constitucionais. A ecografia revelou massa pancreática e formações nodulares hepáticas compatíveis com lesões secundárias, resultado posteriormente corroborado por tomografia computorizada, que acrescentou critérios de irressecabilidade, nomeadamente invasão dos vasos mesen- téricos e do duodeno. A biopsia ecoguiada obteve material cujo estudo anatomopatológico revelou tratar-se de adeno- carcinoma do pâncreas. Iniciou quimioterapia, verifican- do-se melhoria clínica progressiva. A reavaliação imagio- lógica, após 7 ciclos de tratamento, não detectou a lesão primitiva nem as lesões secundárias, sugerindo resposta completa. Foi mantido esquema regular de quimioterapia, persistindo a remissão 8 meses após a documentação da resposta completa.
- Alterações precoces dos enzimas hepáticos após colecistectomia: estudo prospectivo incluindo cintigrafia hepatobiliar quantificadaPublication . Milheiro, A; Diogo, C; Lapa, P; Cunha, MJ; Manso, E; Martins, L; Mártires, E; Pedroso de Lima, J; Castro e Sousa, F
- Articular lymphoscintigraphy in human knees using radiolabeled dextranPublication . Albuquerque, M; Pedroso de Lima, J
- Cintigrafia óssea no diagnóstico de fractura do escafóidePublication . Lapa, P; Ferrer-Antunes, A; Lima, J
- Cintigrafia osteoarticular com polifosfato de 99mTc em doentes com mieloma múltiploPublication . Plácido, F; Pereira, ML; Pedroso de Lima, J; Tavares, JF; Branco, JR
- Cintigrama com leucócitos marcados numa situação de megacolon toxicoPublication . Doménech, A; Cunha, MJ; Pereira, L; Ferrer-Antunes, A; Isidoro, J; Pedroso de Lima, J
- Clinical relevance of incidental colonic uptake 18F-FDG PET/CT. Correlation with colonoscopy and histopathologyPublication . Fernandes, H; Lapa, P; Costa, G; Correia, J; Pedroso de Lima, J
- Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trialPublication . Iagaru, A; Mittra, E; Mosci, C; Dick, DW; Sathekge, M; Prakash, V; Iyer, V; Lapa, P; Isidoro, J; Pedroso de Lima, JM; Gambhir, SS(18)F-FDG PET/CT is used in a variety of cancers, but because of variable rates of glucose metabolism, not all cancers are reliably identified. (18)F(-) PET/CT allows for the acquisition of highly sensitive and specific images of the skeleton. We prospectively evaluated combined (18)F(-)/(18)F-FDG as a single PET/CT examination for evaluation of cancer patients and compared it with separate (18)F(-) PET/CT and (18)F-FDG PET/CT scans. METHODS: One hundred fifteen participants with cancer were prospectively enrolled in an international multicenter trial evaluating (18)F(-) PET/CT, (18)F-FDG PET/CT, and combined (18)F(-)/(18)F-FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. RESULTS: (18)F(-)/(18)F-FDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of (18)F-FDG PET/CT. In 19 participants, skeletal disease was more extensive on (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT than on (18)F-FDG PET/CT. In another 29 participants, (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT showed osseous metastases where (18)F-FDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. CONCLUSION: This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials.
- Detection and Localization of Sentinel Lymph Nodes in Patients with Melanoma. The Added Value of SPECT/CT.Publication . Albuquerque, A; Lapa, P; Moreira, A; Correia, J; Macedo, R; Costa, G; Vieira, R; Figueiredo, A; Pedroso de Lima, J
- Detection of unknown primary tumors using 18F-FDG PET/CTPublication . Fernandes, H; Lapa, P; Costa, G; Correia, J; Pedroso de Lima, J