Dermatologia
Permanent URI for this community
Browse
Browsing Dermatologia by Title
Now showing 1 - 10 of 157
Results Per Page
Sort Options
- Adverse cutaneous reactions to epidermal growth factor receptor inhibitors: a study of 14 patientsPublication . Santiago, F; Gonçalo, Margarida; Reis, JP; Figueiredo, ABACKGROUND: Cetuximab and erlotinib, epidermal growth factor receptor inhibitors, often cause peculiar adverse cutaneous reactions. OBJECTIVES: Our aim was to evaluate adverse cutaneous reactions and their management in patients undergoing treatment with cetuximab and erlotinib. PATIENTS AND METHODS: Between March/2005 and September/2009, we observed 14 patients with a mean age of 59.6 years undergoing treatment with cetuximab (7) or erlotinib (7), due to lung(10) or colorectal cancer (4). We evaluated the interval between introduction of the drug and onset of symptoms, treatment response, and the clinical pattern of evolution of the cutaneous reaction retrospectively. RESULTS: Twelve patients presented papular-pustular eruption typically affecting the face, chest and back, which appeared in average 13.5 days after starting the drug treatment. The patients underwent oral treatment with minocycline or doxycycline and topical treatment with metronidazole, benzoyl peroxide and/or corticosteroids. All patients showed improvement of the lesions. Five patients presented periungual pyogenic granulomas, which were associated with paronychia in 4 cases, after an average of 8 weeks of treatment. There was improvement of the lesions with topical treatment (antibiotics, corticosteroids and antiseptics). Xerosis was observed in some patients. Other less frequent adverse side effects such as telangiectasia and angiomas, hair and eyelash alterations, and eruptive melanocytic nevi were also described. Treatment with epidermal growth factor receptor inhibitor was maintained in most patients. CONCLUSION: The increasing use of these targeted therapies requires knowledge of their adverse cutaneous side effects to ensure timely intervention in order to allow the continuation of the therapy.
- Airborne irritant contact dermatitis and conjunctivitis after occupational exposure to chlorothalonil in textilesPublication . Lensen, G; Jungbauer, F; Gonçalo, Margarida; Coenraads, PJChlorothalonil (tetrachloro-1,3-benzenedicarbonitrile, CAS 1897-45-6) is a pesticide that has been on the market for many years. It is used as a fungicide in agriculture, horticulture, and floriculture; as a wood preservative; and in paint. We report an epidemic of airborne irritant contact dermatitis, conjunctivitis, and upper airway complaints among seamstresses in a Portuguese trailer tent factory, which we attribute to chlorothalonil. All exposed workers had work-related skin symptoms. After patch testing, we showed that none of these were of allergic origin. Instead of allergic reactions, we noticed a delayed type of irritation after 72 hr to chlorothalonil and to the textile extracts containing high concentrations of chlorothalonil. Although allergic and irritant contact dermatitis from chlorothalonil has been described before, this is, as far as we know, the first time that a delayed type of dermatitis, conjunctivitis, and upper airway irritation after exposure to chlorothalonil in tent-cloth is described.
- Allergic and irritant occupational contact dermatitis from AlstroemeriaPublication . Mascarenhas, R; Robalo-Cordeiro, M; Fernandes, B; Oliveira, HS; Gonçalo, Margarida; Figueiredo, A
- Allergic contact and systemic dermatitis to estradiolPublication . Gonçalo, Margarida; Oliveira, HS; Monteiro, C; Clerins, J; Figueiredo, A
- Allergic contact dermatitis from Dittrichia viscosa (L.) GreuterPublication . Gonçalo, S; Gonçalo, Margarida9 cases of contact sensitivity to Dittrichia viscosa, mainly with an airborne pattern, are described. All patients reacted to the fresh leaf of the plant and to its ethereal extracts at 1 and 0.5% pet., and some of them also to that at 0.1% pet. Positive reactions to Frullania dilatata, Laurus nobilis, some other members of the Compositae, and helenin were observed, suggesting the diagnosis of a sesquiterpene-lactone-induced allergic contact dermatitis.
- Allergic contact dermatitis from erythromycinPublication . Martins, C; Freitas, JD; Gonçalo, Margarida; Gonçalo, S
- Allergic contact dermatitis from minoxidilPublication . Ruas, E; Gonçalo, Margarida; Figueiredo, A; Gonçalo, S
- Allergic contact dermatitis from Nicotiana tabacumPublication . Gonçalo, Margarida; Couto, J; Gonçalo, S
- Allergic contact dermatitis from photobonded acrylic gel nails: a review of four cases.Publication . Cravo, M; Cardoso, JC; Gonçalo, Margarida; Figueiredo, A
- Allergic contact dermatitis in children. A multicenter study of the Portuguese Contact Dermatitis Group (GPEDC)Publication . Gonçalo, S; Gonçalo, Margarida; Azenha, A; Barros, MA; Sousa-Bastos, A; Brandão, FM; Faria, A; Marques, MS; Pecegueiro, M; Rodrigues, JB; Salgueiro, E; Torres, VThe authors report a study of allergic contact dermatitis in 329 Portuguese children of 14 years or younger. 170 children (64 male and 106 female) reacted to 1 or more allergens. Most of these were in the 11-14 years group. The main allergens were nickel, thimerosal, cobalt, mercury, fragrance-mix and potassium dichromate. Nickel reactivity predominated in females over the whole group, but a greater number of males younger than 5 years reacted to nickel. The number of positive reactions increased with age, but this was not accompained by an increase in the % of relevant tests. 12 children, all of them 13 or 14 years-old, had an occupational allergic contact dermatitis.