Repository logo

Browsing by Author "Loureiro, G"

Now showing 1 - 10 of 30
  • Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal.
    Publication . Loureiro, G; Rabaça, MA; Blanco, B; Andrade, S; Chieira, C; Pereira, C
    Cova da Beira is an interior central region of Portugal, with a population of 93,000 inhabitants. The first pollen counts performed in Portugal revealed the highest values of the country in this area. The aim of this study was to assess the aeroallergens sensitization in an allergic population, according to the age groups. In a 5 year period (1995-2000) 1790 consecutive outpatients were observed for suspected allergic symptoms. We included in this study all the 557 paediatric (< or = 15 years old) observed patients (317 male (57%) and 240 female (43%) with an average age of 7.6 < or = 4.2 years old). They were divided in three age groups (Group I: < or = 5 yr; Group II: 6-10 yr; Group III: 11-15 yr). 371 patients were submitted to skin prick tests to aeroallergens. 86.5% of these patients were sensitised to at least one allergen extract. The most representative aeroallergens sensitization were grasses mixture (44.9%), D. pteronyssinus (32.5%), D. farinae (29.1%), Olea europea (27.5%), Parietaria judaica (23.4%), cat dander (16.1%), Artemisia vulgaris (17.6%), Robinia pseudoacacia (12.2%), Platanus acerifolia (11.4%), Tilia cordata (11.4%) moulds mixture (11.2%), Plantago lanceolata (10.6%), dog dander (10.4%), and Pinus radiata (7.5%). The sensitisation to indoor aeroallergens, was similar in all age groups and it was less important than that of pollens. The prevalence of sensitisation to grasses was the greatest in all ages and the house dust mites sensitization was the second most prevalent. The highest pollens counts in this region could explain the early sensitisation even in young children.
    2005Journal article Open access Show more
  • Airways hyperresponsiveness to different inhaled combination therapies in adolescent asthmatics
    Publication . Machado, D; Pereira, C; Tavares, B; Loureiro, G; Segorbe-Luís, A
    2012Journal article Open access Show more
  • Body mass index and airway hyper-responsiveness in individuals without respiratory disease
    Publication . Machado, D; Tavares, B; Loureiro, G; Conde, B; Cemlyn-Jones, J; Calado, G; Sousa, N; Chieira, C; Pereira, C
    BACKGROUND: Overweight and obesity are major health issues in Western societies. They are related with a higher risk of different co-morbidities but their relationship with airway hyperresponsiveness (AHR) is still under discussion. Nevertheless, they are related to higher severity in asthma and other respiratory diseases. The aim of the study was to analyze the AHR in individuals with normal lung function without respiratory disorders, according to body mass index (BMI) calculation. METHODS: We performed clinical observation and basal lung function tests (LFT) in 595 consecutive individuals in order to exclude respiratory disease. 377 individuals fulfilled the criteria of normal values according international guidelines. They were submitted to standardized treadmill exercise test followed by bronchodilator test. FVC, FEV1, FEF 25/75, RV and Raw were obtained at different conditions according to BMI groups (I: lean; II: normal; III: overweight; IV obese). RESULTS: 55.2% of the sample was overweight or obese, and a signficant relationship was found with female gender and older ages (p=0.0046 and p<0.0001 respectively). The positive response to exercise test or bronchodilator beta2 agonists was not significantly frequent compared with the other groups. In obese individuals the exercise markedly reduced basal Raw and increased FEF 25/75. Lean individuals showed higher basal values of RV that was reduced upon exercise. Response to 12 agonists showed no differences according to weight biotypes. CONCLUSION: BMI hampers lung function in normal individuals, and seems not to be related to AHR. Regular exercise should be encouraged in overweight and obese individuals, since it increases their bronchial permeability as shown in lower frequency of positive exercise tests. The same is advisable for lean individuals for different reasons. Their increased basal RV and Raw improve upon exercise. Despite overweight and obesity are being related to a low-grade of basal systemic inflammation, there was no association with a higher basal bronchial hyperresponsiveness in these individuals.
    2008Journal article Open access Show more
  • CD4 CD86 expression on experimental allergic murine model
    Publication . Pereira, C; Paiva, A; Machado, D; Henriques, A; Abrantes, M; Laranjo, M; Tavares, B; Loureiro, G; Chieira, C; Botelho, F; Baganha, MF
    2009Journal article Open access Show more
  • Characterisation of disease and exacerbations in patients hospitalized with asthma attacks without previous attendance of a specialized department
    Publication . Calado, G; Loureiro, G; Tavares, B; Pereira, C; Ribeiro, C; Machado, D; Chieira, C
    2008Journal article Open access Show more
  • Chronic rhinosinusitis with nasal polyps in allergic patients
    Publication . Sousa, N; Santos, A; Loureiro, G; Tavares, B; Loureiro, C; Faria, E; Chieira, C
    2008Journal article Open access Show more
  • Clinical respiratory allergy patterns in pairs of siblings
    Publication . Calado, G; Loureiro, G; Tavares, B; Pereira, C; Ribeiro, C; Machado, D; Chieira, C
    2008Journal article Open access Show more
  • Dermatite endógena induzida pela ingestão de níquel: a propósito de dois casos clínicos
    Publication . Carrapatoso, I; Loureiro, G; Loureiro, C; Faria, E; Todo-Bom, A; Chieira, C
    A sensibilização ao níquel representa uma das principais causas de dermatite de contacto alérgica. Um número significativo de doentes apresenta lesões cutâneas, em locais que não estão em contacto directo com este metal. Nos últimos anos a influência do conteúdo em níquel da dieta na evolução da dermatite ao níquel tem merecido particular atenção. Descrevem-se os casos de duas doentes com dermatite de contacto ao níquel em que, apesar da evicção total do contacto com este metal, persistiam lesões de dermatite eczematosa, predominando nas zonas de maior sudação. Com a exclusão da dieta de alimentos com alto teor em níquel observou-se uma redução progressiva da intensidade do eczema, conducente ao desaparecimento total das lesões. As doentes foram, então, submetidas a prova de provocação oral com sulfato de níquel. Na primeira doente estudada observou-se aparecimento de eritema, prurido e reacção eczematosa, generalizados, doze horas após a ingestão de 20 mg de sulfato de níquel. Concomitantemente verificou-se a ocorrência de eritema pruriginoso e pequenas vesículas, no local de aplicação do patch teste ao níquel. No segundo caso a reactivação da dermatite ocorreu seis horas após a ingestão de 10 mg de sulfato de níquel. A manutenção de dieta restritiva em alimentos com alto teor em níquel permitiu o desaparecimento total da dermatite e estabilização clínica que se mantém desde há 6 meses. O diagnóstico de dermatite endógena induzida pela ingestão de níquel foi demonstrado através da realização de prova de provocação oral. A excreção de níquel através do suor parece ser relevante. A redução da ingestão diária de níquel, permitindo a menor concentração deste elemento no suor poderá explicar a melhoria da dermatite, particularmente, nas zonas cutâneas de maior sudação.
    2004Journal article Open access Show more
  • Dermatite herpetiforme como manifestação inicial de doenças celíaca durante a gravidez: caso clínico
    Publication . Calado, G; Loureiro, G; Ribeiro, C; Machado, D; Tavares, B; Chieira, C
    A doença celíaca (DC) é uma enteropatia induzida pela gliadina dos cereais. A prevalência tem vindo a aumentar, designadamente os casos atípicos e em idade adulta, comparativamente à apresentação clássica da infância, com manifestações gastrintestinais e decorrentes da malabsorção. Apresentamos um caso clínico de DC que se manifestou em idade adulta e cuja forma de apresentação foi a dermatite herpetiforme, durante a gravidez. Após um correcto enquadramento clínico e instituição de dieta sem glúten, verificou-se estabilização clínica. No entanto, a doente apresenta esterilidade secundária. Discute -se a interacção entre a DC e a gravidez, já que não só a DC pode ter repercussões na gravidez, como o inverso também se verifica.
    2008Journal article Open access Show more
  • Egg allergy and Hodgkin´s lymphoma: case report
    Publication . Calado, G; Loureiro, G; Machado, D; Ribeiro, C; Tavares, B; Pereira, C; Chieira, C
    2008Journal article Open access Show more