Browsing by Author "Lapa, P"
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- Adenocarcinoma do pâncreas localmente avançado e metastizado com resposta completa a quimioterapiaPublication . Freire, P; Coelho, AJ; Rodrigues, A; Silva, MR; Lapa, P; Graça, B; Porto, AOs autores apresentam o caso clínico de doente do sexo feminino, 54 anos, raça branca, que recorreu ao médico assistente por dor abdominal associada a manifestações constitucionais. A ecografia revelou massa pancreática e formações nodulares hepáticas compatíveis com lesões secundárias, resultado posteriormente corroborado por tomografia computorizada, que acrescentou critérios de irressecabilidade, nomeadamente invasão dos vasos mesen- téricos e do duodeno. A biopsia ecoguiada obteve material cujo estudo anatomopatológico revelou tratar-se de adeno- carcinoma do pâncreas. Iniciou quimioterapia, verifican- do-se melhoria clínica progressiva. A reavaliação imagio- lógica, após 7 ciclos de tratamento, não detectou a lesão primitiva nem as lesões secundárias, sugerindo resposta completa. Foi mantido esquema regular de quimioterapia, persistindo a remissão 8 meses após a documentação da resposta completa.
- Alterações precoces dos enzimas hepáticos após colecistectomia: estudo prospectivo incluindo cintigrafia hepatobiliar quantificadaPublication . Milheiro, A; Diogo, C; Lapa, P; Cunha, MJ; Manso, E; Martins, L; Mártires, E; Pedroso de Lima, J; Castro e Sousa, F
- Cintigrafia óssea no diagnóstico de fractura do escafóidePublication . Lapa, P; Ferrer-Antunes, A; Lima, J
- Clinical relevance of incidental colonic uptake 18F-FDG PET/CT. Correlation with colonoscopy and histopathologyPublication . Fernandes, H; Lapa, P; Costa, G; Correia, J; Pedroso de Lima, J
- Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trialPublication . Iagaru, A; Mittra, E; Mosci, C; Dick, DW; Sathekge, M; Prakash, V; Iyer, V; Lapa, P; Isidoro, J; Pedroso de Lima, JM; Gambhir, SS(18)F-FDG PET/CT is used in a variety of cancers, but because of variable rates of glucose metabolism, not all cancers are reliably identified. (18)F(-) PET/CT allows for the acquisition of highly sensitive and specific images of the skeleton. We prospectively evaluated combined (18)F(-)/(18)F-FDG as a single PET/CT examination for evaluation of cancer patients and compared it with separate (18)F(-) PET/CT and (18)F-FDG PET/CT scans. METHODS: One hundred fifteen participants with cancer were prospectively enrolled in an international multicenter trial evaluating (18)F(-) PET/CT, (18)F-FDG PET/CT, and combined (18)F(-)/(18)F-FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. RESULTS: (18)F(-)/(18)F-FDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of (18)F-FDG PET/CT. In 19 participants, skeletal disease was more extensive on (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT than on (18)F-FDG PET/CT. In another 29 participants, (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT showed osseous metastases where (18)F-FDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. CONCLUSION: This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials.
- Detection and Localization of Sentinel Lymph Nodes in Patients with Melanoma. The Added Value of SPECT/CT.Publication . Albuquerque, A; Lapa, P; Moreira, A; Correia, J; Macedo, R; Costa, G; Vieira, R; Figueiredo, A; Pedroso de Lima, J
- Detection of unknown primary tumors using 18F-FDG PET/CTPublication . Fernandes, H; Lapa, P; Costa, G; Correia, J; Pedroso de Lima, J
- Efeitos secundários da castração com goserelina em mulheres com cancro da mamaPublication . Franco, S; Lapa, P; Guerra, C; Pereira, L; Oliveira, CFIn the last few years, ovarian ablation with GnRH agonists has been used as first-line adjuvant therapy in pre and perimenopausal breast cancer. These drugs suppress ovarian function in the hypothalamic-pituitary axis and they have adverse effects in other end-organs. A retrospective study was conducted on 35 premenopausal women, with breast cancer, and treated with goserelin, in order to investigate the effects of iatrogenic estrogen suppression. All women complaint of amenorrhea and only half of them referred hot-flashes, weight gain or arthralgias. Hot-flushes and arthralgias remit spontaneously in the end of the treatment. Osteodensitometry was used to access bone mass. There was a reduction in mineral bone mass and T-score at femoral neck and lumbar spine after the treatment with goserelin, but without statistical significance, except for the T-score in lumbar spine.
- Gânglio sentinela no cancro da vulva, colo e endométrioPublication . Correia, P; Oliveira, V; Cruz, I; Duarte, H; Lourenço, C; Amaral, N; Mota, F; Silva, T; Lapa, P; Pedroso de Lima, J; Oliveira, CF
- Incidental Detection of 18F-FDG Thyroid Uptake: The Risk of MalignancyPublication . Correia, J; Lapa, P; Albuquerque, A; Macedo, R; Silva, R; Fernandes, H; Costa, G; Pedroso de Lima, J