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Browsing by Author "Bento, J"

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  • 2013Lecture Open access Show more
  • Doseamento das granzimas A e B na sarcoidose pulmonar (estudo experimental)
    Publication . Dourado, M; Bento, J; Mesquita, L; Marques, A; Vale-Pereira, S; Ribeiro, AB; Mota-Pinto, A
    Sarcoidosis is a systemic disease of unknown aetiology, morphologically characterized by well-formed epithelioid granulomas, which show little or no central necrosis. These may be present in any organ or tissue. The lung is the most frequently and prominently involved target. The granuloma is often very sharply demarcated from the adjacent tissue and is surrounded by a mantle of lymphocytes, which mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins, perforins and granzymes. Sarcoidosis laboratorial diagnosis is usually made by SACE and Lisozyme dosages. The granzymes A and B could be two other markers of the disease, since the sarcoidosis granuloma is rich in cytotoxic and NK cells. An ELISA Kit was used to measure Granzyme A and B in serum of a normal control group (NC) (n=30), and in two groups with lung pathology: one without sarcoidosis, disease control (DC) (n=21) and other with sarcoidosis (S) (n=11). Our results showed that SACE activity is significantly augmented in S group comparing with NC and DC, respectively: 82,6+/-32,7/31,9+/-17,8 - p=0,00017 and 82,6+/-32,7/31,9+/-17,8 - p=0,00024. Lisozyme activity is significantly augmented in S and DC groups comparing with NC. Granzyme B showed a significant decrease in DC and S groups comparing with NC. Granzyme A showed a significant decrease between S/NC groups. Our results suggest that the decrease of Granzyme A and B in sarcoidotic patients could be related to an ineffective inflammatory local response related to the formation of sarcoidosis granulomas. More studies are needed, particularly in BAL.
    2005Journal article Open access Show more
  • Hallux valgus: images of surgical procedures and algorithmic approach
    Publication . Mariano, C; Bento, J; Faísca, J; Judas, F
    Different types and aetiologies of hallux valgus have been described, as well as several surgical procedures. Surgery outcome depends on correct bone alignment, placing first metatarsal over sesamoid bones, on joint congruity restoration and on soft tissues balancing. Despite surgical treatment, recurrence of deformity is common. Other foot problems may also coexist, such as hammer toe or flatfoot syndrome, metatarsalgia or small joints arthrosis. Surgery is reserved for patients who fail conservative treatment. It consists on soft tissue management and bone procedures. The best surgical correction and fixation techniques are still to be determined. Each patient must be assessed thoroughly and treatment should take into account patient’s deformity, comorbidities and expectations and also surgeon’s experience. This work focuses on an algorithmic approach to hallux valgus surgical treatment.
    2012Lecture Open access Show more
  • Osteogénese por distracção – velocidade de crescimento do regenerado ósseo, em pseudartrose séptica da tíbia
    Publication . Nascimento, M; Carvalho, M; Bento, J; Garruço, A; Fonseca, F
    2013Conference object Open access Show more