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Browsing by Author "Andrade, A"

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  • Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus
    Publication . Henriques, A; Inês, L; Carvalheiro, T; Couto, M; Andrade, A; Pedreiro, S; Laranjeiro, P; Morgado, JM; Pais, ML; Pereira da Silva, JA; Paiva, A
    With the purpose of contributing to a better knowledge of the APCs functional activity in SLE, we evaluated the distribution and functional ability to produce pro-inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-12) of peripheral blood (PB) monocytes and DC (tDC), particularly myeloid (mDC) and CD14(-/low)CD16(+) DC subpopulations comparing them with those obtained from healthy individuals. The study was performed in 34 SLE patients with diverse disease activity scores (SLEDAI) and 13 healthy age- and sex-matched controls (NC). Our results show an overall decrease in absolute number and relative frequency of tDC in SLE patients with active disease when compared to those with inactive disease and NC, although this decrease did not seem to have an effect on the distribution of PB DC subsets. The monocytes number in SLE patients was similar to those found in NC, whereas a higher frequency of monocytes producing cytokines as well as the amount of each cytokine per cell found without stimulation was particularly observed in those patients with active disease. After stimulation, we observed a higher frequency of IL-12-producing monocytes in active SLE patients. On the other hand, we found among DCs higher frequencies of cytokine-producing CD14(-/low)CD16(+) DCs and a higher amount of cytokines produced per cell, particularly in active disease. These findings support an increased production of inflammatory cytokines by APCs in active SLE, mostly associated with alterations in CD14(-/low)CD16(+) DC subset homeostasis that might contribute to explain the dynamic role of these cells in disease pathogenesis
    2011Journal article Open access Show more
  • Sinovectomia, realinhamento e estabilização do punho dorsal reumatóide
    Publication . Judas, F; Dominguez, A; Andrade, A; Quental, J; Proença, A
    A sinovectomia, realinhamento e estabilização do punho dorsal reumatóide (S.R.E.), consiste numa sinovectomia tendinosa e articular associada a transferência tendinosa do 1º radial para o 2º radial, à artrodese rádio-cubital inferior (operação de Sauvé-Kapandji) e, a uma plastia do ligamento anular dorsal do carpo. Foram estudados 16 punhos reumatóides submetidos a uma S.R.E., com um tempo médio de evolução de 3 anos e 5 meses, utilizando critérios clínicos e radiológicos. Houve uma melhoria significativa em relação à dor, com conservação da mobilidade residual do punho. O colapso rádio-cárpico foi ligeiro, a translação cubital do carpo não foi significativa, embora o tempo de evolução seja insuficiente para tirar conclusões definitivas. Como complicações, registámos uma ossificação entre as osteotomias do cúbito e um caso de migração do parafuso. A S.R.E. está indicada nos graus radiológicos II e III de Larsen, podendo ser alargada ao grau IV com um resultado satisfatório.
    2000Journal article Open access Show more