Browsing by Author "Amaral, N"
Now showing 1 - 10 of 11
Results Per Page
Sort Options
- Atipias glandulares de significado indeterminado (AGUS) que entidade ?Publication . Pires, MA; Rebelo, MT; Dias, MF; Amaral, N; Dinis, M; Oliveira, CF; Oliveira, HM
- Avaliação dos resultados da biópsia do gânglio sentinela no carcinoma da mamaPublication . Saleiro, S; Rodrigues, AC; Frutuoso, C; Guerra, C; Coimbra, C; Amaral, N; Oliveira, CF
- Carcinoma in situ and early breast carcinoma survey of the Portuguese Senology Society on treatment in Portugal and its evolution between 1985 and 2000Publication . Oliveira, CF; Rodrigues, V; Gervásio, H; Pereira, JM; Albano, J; Amaral, NBy means of a questionnaire sent to Portuguese hospitals which diagnose and treat most female patients with breast cancer, it was intended to assess the situation regarding the treatment of carcinoma in situ and early breast cancer (T1 or T2, N0 or N1), as well as their evolution between 1985 and 2000. The hospital participation rate was 65% and a sample of 865 patients was collected, distributed by the years 1985, 1990, 1995 and 2000. It was observed that, in terms of surgery, there was an increase in conservative surgery, which was over 40% in 2000, as well as an increase in the average of excised axillary lymph nodes. Progress in the surgical approach was similar both in cancer centres and in large and university hospitals, when compared with the other surveyed hospitals. Also, no differences between these two hospital groups in disease-free survival and overall survival were found. Postoperative radiotherapy was employed in more than 90% of the patients submitted to conservative surgery and adjuvant chemotherapy was used in 39% of all the patients, while tamoxifen as adjuvant treatment was used in 58% of the patients.
- Gânglio sentinela no cancro da vulva, colo e endométrioPublication . Correia, P; Oliveira, V; Cruz, I; Duarte, H; Lourenço, C; Amaral, N; Mota, F; Silva, T; Lapa, P; Pedroso de Lima, J; Oliveira, CF
- Operação de Wertheim-Meigs: Resultados de 10 anosPublication . Frutuoso, C; Amaral, N; Marques, C; Oliveira, CF; Oliveira, HMWertheim-Meigs hysterectomy is used in the treatment of cervical cancer, but since 1988 we have also used it to stage and treat endometrial carcinoma. To evaluate the morbidity of Wertheim Meigs hysterectomy as well as node invasion incidence and its correlation with other prognostic factors, the authors made a retrospective study of 112 patients, from October 1986 to March 1996. Among the 112 cases evaluated, 52% had cervical carcinoma and 48% had endometrial carcinoma; mean ages were 45 +/- 10 and 60 +/- 8 years (p < 0.005). FIGO stage distribution was: I-94.8 and 33.3%; II-5.2 and 51.9%; III-0 and 13%; IV-0 and 1.8%, for cervical and endometrial carcinoma. Hemorrhagic and traumatic accidents happened in 24.3% and 1.7% respectively. We had 15.5% early post operative complications and 1.7% late post operative ones. The mean duration of surgery and hospitalization was 163 +/- 29 minutes and 10 +/- 5 days. Pelvic lymphadenectomy was performed in 70% of patients and para-aortic nodes were also excised in the other 30%. The mean number of lymphatic nodes excised were 17 +/- 9. Pelvic node invasion was found in 9% and in 3.7% of para-aortic ones. When we studied endometrial cancer, we found a positive correlation between external myometrium invasion and lymphovascular invasion and positive node (p < 0.05). From the data available we may conclude that the complication rate of Wertheim Meigs is quite important, even though all but one complication were transitory. It may be possible to make a better selection of patients who need this surgical procedure by correct evaluation of risk factors.
- Paraovarian tumor of borderline malignancy: a case reportPublication . Areia, AL; Frutuoso, C; Amaral, N; Dias, I; Oliveira, CFA case of a 23-year-old woman with a paraovarian tumor is presented. The patient complained of pelvic pain and abdominal swelling. Cystectomy was the initial surgical treatment, but after the histological diagnosis, a staging surgery was carried out. The clinical aspects and subsequent management of related cases are discussed, and a literature review is made.
- Sclerosis of gross cysts of the breast: a three-year studyPublication . Gomes, C; Amaral, N; Marques, C; Borralho, R; Oliveira, CFBreast cysts can be separated into two types: Type I cyst with a lining epithelium which shows apocrine metaplasia, and Type II cyst with an epithelium which is markedly attenuated or absent. The risk of subsequent breast cancer among patients with Type I cysts can be up to 4. The standard treatment is fine needle aspiration, but 20% of the cysts recur. Pharmacological treatment has been tried, which reduces size and volume, but has side-effects and a high recurrence rate post-treatment occurs. The objectives of this prospective study were to sclerose the cyst, induce its regression and prevent or reduce recurrence rate, with the administration of a sclerosing solution (Sclerovein) within the cyst post-aspiration. Fifty-seven patients were followed in the study, 37 with Type I cysts and 20 with Type II cysts. At the end of six months all patients with Type II cysts had no detectable cyst. On the other hand, two patients still had a residual Type I cyst. At the end of three years our recurrence rate appears to be less than 2%, with one patient with a possible recurrence. No significant side-effects were observed. The use of Sclerovein is a simple and safe alternative in the treatment of recurring cysts.
- Sentinel node in breast cancer: preliminary results obtained at Gynaecology Department of the University Hospital of CoimbraPublication . Oliveira, V; Cruz, I; Amaral, N; Lapa, P; Oliveira, S; Silva, T; Martins, MI; Pedroso de Lima, J; Oliveira, CF
- Tumor desmoide simulando carcinoma da mama: um caso clínicoPublication . Cortesão, P; Andrade, MJ; Franco, S; Carvalho, G; Sousa, R; Silva, T; Torgal, I; Amaral, N; Oliveira, CF
- Valor prognóstico das proteínas p53, C-erB-2 E Ki67 no carcinoma do ovárioPublication . Frutuoso, C; Silva, MR; Amaral, N; Martins, MI; Oliveira, CF; Oliveira, HMThe prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 67 expression by immunohistochemistry. The results were: age 5.4 +/- 15(22-88); 66% with normal physical activity; 48.2% with residual disease < 2 cm; initial stage--42% and advanced stage--58%. Age, performance status, residual disease and stage were correlated with 2 and 5 years survival. Positive immunostaining: p53--87%, C-erb B-2--51% and Ki67--100%. P53 and C-erb B-2 were associated with residual disease and stage; patients with no C-erbB-2 staining had a significantly better survival. A direct and significant correlation was found between p53 and Ki67 and between C-erb B-2 and p53. We conclude that these markers have a high expression in ovarian carcinoma and p53 and C-er B-2 correlate with stage and residual disease. Although C-erb B-2 was associated with better survival, it was not found to be an independent prognostic factor.