Publication
Cast nephropathy: an extremely rare renal presentation of Waldenström's macroglobulinaemia
| dc.contributor.author | Santos, T | |
| dc.contributor.author | Machado, S | |
| dc.contributor.author | Sousa, V | |
| dc.contributor.author | Campos, M | |
| dc.date.accessioned | 2016-05-11T15:46:04Z | |
| dc.date.available | 2016-05-11T15:46:04Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Renal involvement in Waldenström's macroglobulinaemia (WM) is very unusual when compared to multiple myeloma. We report a case of a patient who developed anuric acute kidney injury secondary to cast nephropathy, dependent on high-flux haemodialysis. Complementary study revealed the presence of blood IgM monoclonal gammopathy and a massive bone marrow lymphoplasmacytic infiltration. There were no osteolytic lesions and no clinical signs/symptoms of hyperviscosity syndrome. The diagnosis of WM was established and a dexamethasone plus cyclophosphamide regime was started, in addition to plasmapheresis. The patient partially recovered renal function allowing haemodialysis and plasmapheresis withdrawal. He remained asymptomatic with a good response to chemotherapy and 12 months after his renal function remained stable. This is a rare clinical case in which WM presented as an IgM cast nephropathy, which in turn is an extremely rare renal presentation of this equally rare haematological disorder. | pt_PT |
| dc.identifier.citation | BMJ Case Rep. 2015 Oct 7;2015. pii: bcr2015211210 | pt_PT |
| dc.identifier.doi | 10.1136/bcr-2015-211210 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1896 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Doenças do Rim | pt_PT |
| dc.subject | Macroglobulinemia de Waldenstrom | pt_PT |
| dc.title | Cast nephropathy: an extremely rare renal presentation of Waldenström's macroglobulinaemia | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |