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Continuous infusion of piperacillin/tazobactam in septic critically ill patients--a multicenter propensity matched analysis

dc.contributor.authorGonçalves-Pereira, J
dc.contributor.authorOliveira, BS
dc.contributor.authorJaneiro, S
dc.contributor.authorEstilita, J
dc.contributor.authorMonteiro, C
dc.contributor.authorSalgueiro, A
dc.contributor.authorVieira, A
dc.contributor.authorGouveia, J
dc.contributor.authorPaulino, C
dc.contributor.authorBento, L
dc.contributor.authorPóvoa, P
dc.date.accessioned2013-06-18T17:00:24Z
dc.date.available2013-06-18T17:00:24Z
dc.date.issued2012
dc.description.abstractThe clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients with microbiologically documented infections is currently unknown. We conducted a retrospective multicenter cohort study in 7 Portuguese intensive care units (ICU). We included 569 critically ill adult patients with a documented infection and treated with piperacillin/tazobactam admitted to one of the participating ICU between 2006 and 2010. We successfully matched 173 pairs of patients according to whether they received continuous or conventional intermittent dosing of piperacillin/tazobactam, using a propensity score to adjust for confounding variables. The majority of patients received 16g/day of piperacillin plus 2g/day of tazobactam. The 28-day mortality rate was 28.3% in both groups (p = 1.0). The ICU and in-hospital mortality were also similar either in those receiving continuous infusion or intermittent dosing (23.7% vs. 20.2%, p = 0.512 and 41.6% vs. 40.5%, p = 0.913, respectively). In the subgroup of patients with a Simplified Acute Physiology Score (SAPS) II>42, the 28-day mortality rate was lower in the continuous infusion group (31.4% vs. 35.2%) although not reaching significance (p = 0.66). We concluded that the clinical efficacy of piperacillin/tazobactam in this heterogeneous group of critically ill patients infected with susceptible bacteria was independent of its mode of administration, either continuous infusion or intermittent dosing.por
dc.identifier.citationPLoS One. 2012;7(11):e49845.por
dc.identifier.urihttp://hdl.handle.net/10400.4/1565
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectBacteriapor
dc.subjectInfecçãopor
dc.subjectUnidade de Cuidados Intensivospor
dc.subjectÁcido Penicilânicopor
dc.subjectPiperacilinapor
dc.titleContinuous infusion of piperacillin/tazobactam in septic critically ill patients--a multicenter propensity matched analysispor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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