Publication
A Importância da Referenciação Precoce na Falência Hepática Aguda Pediátrica
| dc.contributor.author | Jerónimo, M | |
| dc.contributor.author | Moinho, R | |
| dc.contributor.author | Carvalho, L | |
| dc.contributor.author | Gonçalves, I | |
| dc.contributor.author | Furtado, E | |
| dc.contributor.author | Farela-Neves, J | |
| dc.date.accessioned | 2016-03-21T17:15:11Z | |
| dc.date.available | 2016-03-21T17:15:11Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | INTRODUCTION: Acute liver failure is a rare disorder associated to high morbidity and mortality despite survival improvement through liver transplantation. The importance of a multidisciplinary approach and early referral to a pediatric liver transplantation center were important conclusions of a national meeting in 2008, from which resulted an actuation consensus. OBJECTIVES: To characterize acute liver failure admissions in a Pediatric Intensive Care Unit of the portuguese pediatric livertransplantation center. To compare results before (A) and after (B) 2008. MATERIAL AND METHODS: Observational, retrospective study during a 20 year period (1994-2014). INCLUSION CRITERIA: age < 18 years old and acute liver failure (INR ≥ 2 without vitamin K response and hepatocellular necrosis). Children with previous liver disease were excluded. RESULTS: Fifty children were included, with median age of 24.5 months. The most common etiology under 2 years old was metabolic (34.6%) and above that age was infectious (29.2%). Forty six percent were submitted to liver transplantation and 78% of them survived. Overall mortality was 34%. Median referral time was 7 days in period A (n = 35) and 2 days in period B (n = 15; p = 0.006). Pediatric risk of mortality's median was 14.7 in period A and 6.5 in B (p = 0.019). Mortality was 37% vs 26% in periods A and B, respectively (p = 0.474). DISCUSSION AND CONCLUSIONS: Overall mortality was similar to the observed in other European centers. Liver transplantation is in fact the most effective therapeutic option. After 2008, there was a reduction in referral time and cases severity on admission; however, mortality has not reduced so far. | pt_PT |
| dc.identifier.citation | Acta Med Port. 2015 Sep-Oct;28(5):559-66. | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1870 | |
| dc.language.iso | por | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Criança | pt_PT |
| dc.subject | Falência Hepática Aguda | pt_PT |
| dc.subject | Referenciação | pt_PT |
| dc.subject | Transplantação de Fígado | pt_PT |
| dc.title | A Importância da Referenciação Precoce na Falência Hepática Aguda Pediátrica | pt_PT |
| dc.title.alternative | The Importance of Early Referral in Pediatric Acute Liver Failure | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |