Publication
Immune phenotype of chronic liver disease
| dc.contributor.author | Czaja, JA | |
| dc.contributor.author | Santos, R | |
| dc.contributor.author | Porto, A | |
| dc.contributor.author | Santrach, PJ | |
| dc.contributor.author | Moore, SB | |
| dc.date.accessioned | 2009-08-21T15:17:04Z | |
| dc.date.available | 2009-08-21T15:17:04Z | |
| dc.date.issued | 1998 | |
| dc.description.abstract | Immune disorders in chronic liver disease may reflect common host propensities or disease-specific factors. Our aim was to determine the principal bases for these expressions. Four hundred fifty-one patients with various chronic liver diseases were assessed prospectively for concurrent immune disorders. Individuals with immune diseases were more frequently women (73% vs 60%, P = 0.02) and they had HLA DR4 more often than counterparts with other HLA (46% vs 23%, P = 0.000008). The association between HLA DR4 and immune disease was apparent within individual liver diseases and within different categories of liver disease. Women with HLA DR4 had a higher frequency of immune disease than women without HLA DR4 (52% vs 22%, P < or = 0.000001), and they also had immune diseases more commonly than DR4-positive men (52% vs 31%, P = 0.03). DR4-positive men, however, had higher frequencies of immune disease than DR4-negative men, especially in the nonimmune types of liver disease (26% vs 4%, P = 0.002). We conclude that HLA DR4 and female gender constitute an immune phenotype that is an important basis for autoimmune expression in chronic liver disease. | pt |
| dc.identifier.citation | Dig Dis Sci. 1998 Sep;43(9):2149-55 | pt |
| dc.identifier.uri | http://hdl.handle.net/10400.4/554 | |
| dc.language.iso | eng | pt |
| dc.publisher | Springer | pt |
| dc.rights.uri | openAccess | en |
| dc.subject | Doenças do Fígado | pt |
| dc.title | Immune phenotype of chronic liver disease | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.type | article | pt |