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Gastroduodenal tolerability of nimesulide and diclofenac in patients with osteoarthritis

1998Journal article Open access
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dc.contributor.authorPorto, A
dc.contributor.authorReis, C
dc.contributor.authorPerdigoto, R
dc.contributor.authorGonçalves, M
dc.contributor.authorFreitas, P
dc.contributor.authorMacciocchi, A
dc.date.accessioned2009-08-21T14:42:18Z
dc.date.available2009-08-21T14:42:18Z
dc.date.issued1998
dc.description.abstractThis 1-month, randomized, double-masked, parallel-group study was conducted to compare nimesulide (100 mg twice daily) with diclofenac (50 mg three times daily) with respect to gastroduodenal tolerability and efficacy in patients with osteoarthritis. Results of gastroduodenal endoscopy in 83 patients (42 receiving nimesulide, 41 receiving diclofenac) revealed that, after 30 days, 4 patients (1 nimesulide, 3 diclofenac) had developed ulcers and 6 patients (4 nimesulide, 2 diclofenac) had developed erosions; however, differences between the treatment groups were not statistically significant. Both study drugs were well tolerated. Ten patients (5 in each group) withdrew from the study prematurely because of adverse events. Efficacy was assessed by measuring pain on visual analogue scales, using the functional index of Lequesne, and by scoring spontaneous pain, pain on passive movement, and functional impairment. Nocturnal pain was also checked. All efficacy variables showed a significant improvement during the study, and no statistically significant differences were observed between the treatment groupspt
dc.identifier.citationCurrent Therapeutic Research. 59:9 (1998) 654-665pt
dc.identifier.urihttp://hdl.handle.net/10400.4/550
dc.language.isoengpt
dc.rights.uriopenAccessen
dc.subjectOsteoartritept
dc.subjectDiclofenacpt
dc.subjectNimesulidapt
dc.titleGastroduodenal tolerability of nimesulide and diclofenac in patients with osteoarthritispt
dc.typejournal article
dspace.entity.typePublication
rcaap.typearticlept

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