Publication
CA-125 AUC as a new prognostic factor for patients with ovarian cancer
| dc.contributor.author | Mano, A | |
| dc.contributor.author | Falcão, A | |
| dc.contributor.author | Godinho, I | |
| dc.contributor.author | Santos, J | |
| dc.contributor.author | Leitão, F | |
| dc.contributor.author | Oliveira, CF | |
| dc.contributor.author | Caramona, M | |
| dc.date.accessioned | 2008-11-24T16:35:36Z | |
| dc.date.available | 2008-11-24T16:35:36Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | OBJECTIVE: The aim of the present study was to investigate the usefulness of the CA-125 area under the curve (AUC) as a new kinetic parameter for predicting overall survival in patients with ovarian cancer. In addition, the relationship of CA-125 AUC with other prognostic factors of ovarian cancer was evaluated. METHODS: Ninety-two patients that underwent primary line chemotherapy within 4 months after submission to cytoreductive surgery were included. For each patient, CA-125 AUC was calculated and a statistical analysis was conducted to compare CA-125 AUC behavior among patients according to several covariates. RESULTS: The mean age at diagnostic time was found to be 55.5 (16.1-82.4) years with a mean survival of 39.2 (3.5-100.1; SE = 2.6) months. Across FIGO stage I, II, III, and IV patients had a mean CA-125 AUC of 18.2, 24.6, 147.8, and 574.6 IU/ml*days, respectively (P < 0.05). At the evaluation date, living patients had a mean CA-125 AUC of 40.1 in contrast to 234.1 IU/ml*days (P < 0.05) for deceased ones. Patients with a complete response to primary chemotherapy had a mean CA-125 AUC of 48.8, while patients with a partial response had a mean of 251.7 IU/ml*days, and patients with no response or disease progression had a mean of 316.5 IU/ml*days (P < 0.05). The best CA-125 AUC performance is in predicting patient complete response to chemotherapy with a cut-off of 100 IU/ml*days and an accuracy of 82%. CONCLUSIONS: Despite CA-125 AUC high correlation with the FIGO stage, residual disease, and patient final outcome, the main interest of CA-125 AUC calculation is to evaluate the treatment efficacy and to foresee a full chemotherapy response. Further studies should be carried out before extrapolating these results to other data sets. | en |
| dc.identifier.citation | Gynecol Oncol. 2005 May;97(2):529-34 | en |
| dc.identifier.uri | http://hdl.handle.net/10400.4/130 | |
| dc.language.iso | eng | en |
| dc.publisher | Elsevier | en |
| dc.subject | Antigénio CA-125 | en |
| dc.subject | Neoplasias do Ovário | en |
| dc.title | CA-125 AUC as a new prognostic factor for patients with ovarian cancer | en |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | |
| rcaap.type | article | en |