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Predictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention study

dc.contributor.authorMiglior, S
dc.contributor.authorZeyen, T
dc.contributor.authorHoffmann, EM
dc.contributor.authorTorri, V
dc.contributor.authorRulli, E
dc.contributor.authorFloriani, I
dc.contributor.authorPoli, D
dc.contributor.authorAliyeva, S
dc.contributor.authorCunha-Vaz, J
dc.contributor.authorPfeiffer, N
dc.date.accessioned2016-12-12T16:15:24Z
dc.date.available2016-12-12T16:15:24Z
dc.date.issued2015-02
dc.description.abstractPURPOSE: To determine whether baseline Heidelberg Retina Tomograph (HRT) measurements of the optic disc are associated with the development of open-angle glaucoma (OAG) in individuals with ocular hypertension in the European Glaucoma Prevention Study (EGPS). DESIGN: Retrospective analysis of a prospective, randomized, multicenter, double-masked, controlled clinical trial. METHODS: There were 489 participants in the HRT Ancillary Study to the EGPS. Each baseline HRT parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of OAG. Proportional hazards models were used to identify HRT variables that predicted which participants in the EGPS had developed OAG. Development of OAG was based on visual field and/or optic disc changes. RESULTS: At a median follow-up time of about 5 years, 61 participants developed OAG. In multivariate analyses, adjusting for randomization arm, age, baseline IOP, central corneal thickness, pattern standard deviation, and HRT disc area, the following HRT parameters were associated with the development of OAG: the "outside normal limits" classification of the Frederick Mikelberg (FSM) discriminant function (hazard ratio [HR] 2.51, 95% confidence interval [CI]: 1.45-4.35), larger mean cup depth (HR 1.64, 95% CI: 1.21-2.23), cup-to-disc area ratio (HR 1.43, 95% CI: 1.14-1.80), linear cup-to-disc ratio (HR 1.43, 95% CI: 1.13-1.80), cup area (HR 1.33, 95% CI: 1.08-1.64), smaller rim area (HR 1.33, 95% CI: 1.07-1.64), larger cup volume (HR 1.30, 95% CI: 1.05-1.61), smaller rim volume (HR 1.25, 95% CI: 1.01-1.54), larger maximum cup depth (HR 1.18, 95% CI: 1.01-1.36), and cup shape measure (HR 1.18, 95% CI: 1.01-1.36). CONCLUSIONS: Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of OAG among the EGPS participants.pt_PT
dc.identifier.citationAm J Ophthalmol. 2015 Feb;159(2):265-76.e1.pt_PT
dc.identifier.doi10.1016/j.ajo.2014.10.028pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/1998
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectGlaucoma de Ângulo Abertopt_PT
dc.subjectHipertensão Ocularpt_PT
dc.subjectDoenças do Nervo Ópticopt_PT
dc.subjectTécnicas de Diagnóstico Oftalmológicopt_PT
dc.titlePredictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage276.e1pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage265-76.e1pt_PT
oaire.citation.volume159pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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