Imunoalergologia
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Browsing Imunoalergologia by Subject "Alergénios"
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- Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal.Publication . Loureiro, G; Rabaça, MA; Blanco, B; Andrade, S; Chieira, C; Pereira, CCova da Beira is an interior central region of Portugal, with a population of 93,000 inhabitants. The first pollen counts performed in Portugal revealed the highest values of the country in this area. The aim of this study was to assess the aeroallergens sensitization in an allergic population, according to the age groups. In a 5 year period (1995-2000) 1790 consecutive outpatients were observed for suspected allergic symptoms. We included in this study all the 557 paediatric (< or = 15 years old) observed patients (317 male (57%) and 240 female (43%) with an average age of 7.6 < or = 4.2 years old). They were divided in three age groups (Group I: < or = 5 yr; Group II: 6-10 yr; Group III: 11-15 yr). 371 patients were submitted to skin prick tests to aeroallergens. 86.5% of these patients were sensitised to at least one allergen extract. The most representative aeroallergens sensitization were grasses mixture (44.9%), D. pteronyssinus (32.5%), D. farinae (29.1%), Olea europea (27.5%), Parietaria judaica (23.4%), cat dander (16.1%), Artemisia vulgaris (17.6%), Robinia pseudoacacia (12.2%), Platanus acerifolia (11.4%), Tilia cordata (11.4%) moulds mixture (11.2%), Plantago lanceolata (10.6%), dog dander (10.4%), and Pinus radiata (7.5%). The sensitisation to indoor aeroallergens, was similar in all age groups and it was less important than that of pollens. The prevalence of sensitisation to grasses was the greatest in all ages and the house dust mites sensitization was the second most prevalent. The highest pollens counts in this region could explain the early sensitisation even in young children.
- Alergénios / Condicionantes ocultosPublication . Machado, D; Barbosa, C
- Comparison between skin prick tests and ImmunoCAP ISAC in the determination of sensitisation to aeroallergensPublication . Sousa, N; Almeida, E; Machado, D; Rodrigues, F; Carrapatoso, I; Faria, E; Ribeiro, H; Chieira, C
- Comparison of basophil activation test results in blood preserved in acid citrate dextrose and EDTAPublication . Sousa, N; Martínez-Aranguren, R; Fernández-Benitez, M; Ribeiro, F; Sanz, ML
- Fruits, vegetables and latex sensitisation a pollen allergic patientsPublication . Sousa, N; Cruz, M; Carrapatoso, I; Faria, E; Chieira, C
- Hazelnut Allergens: Molecular Characterisation, Detection and Clinical RelevancePublication . Costa, J; Mafra, I; Carrapatoso, I; Oliveira, MBIn the last years, special attention has been devoted to food-induced allergies, from which hazelnut allergy is highlighted. Hazelnut is one of the most commonly consumed tree nuts, being largely used by the food industry in a wide variety of processed foods. It has been regarded as a food with potential health benefits, but also as a source of allergens capable of inducing mild to severe allergic reactions in sensitised individuals. Considering the great number of reports addressing hazelnut allergens, with an estimated increasing trend, this review intends to assemble all the relevant information available so far on the main issues: prevalence of tree nut allergy, clinical threshold levels, molecular characterisation of hazelnut allergens (Cor a 1, Cor a 2, Cor a 8, Cor a 9, Cor a 10, Cor a 11, Cor a 12, Cor a 14 and Cor a TLP) and their clinical relevance, and methodologies for hazelnut allergen detection in foods. A comprehensive overview on the current data about the molecular characterisation of hazelnut allergens is presented, relating biochemical classification and biological function with clinical importance. Recent advances on hazelnut allergen detection methodologies are summarised and compared, including all the novel protein- and DNA-based approaches.
- Sensitization to profilin in the Central region of Portugal.Publication . Tavares, B; Machado, D; Loureiro, G; Cemlyn-Jones, J; Pereira, CBACKGROUND: Profilin is a panallergen found in pollens and fruits. Sensitization to this protein may explain some sensitization to multiple pollen species. We aimed to evaluate sensitization to profilin in patients suffering from respiratory allergy sensitized to pollens, in the Central region of Portugal. METHODS: Patients were evaluated for asthma symptoms, rhinitis, conjunctivitis and food allergy. Skin prick tests (SPT) to aeroallergens including 12 different pollens and profilin (nPho d 2) were performed. The patients were divided into two study groups according to the region of residence: A - inland region and B - coastal region. RESULTS: A total of 370 patients were evaluated (277-group A; 93-group B). 65.9% showed positive skin prick tests and 76.2% were positive to pollens (87.1%-group A; 42.85%-group B; p<0.0001). All the patients sensitized to pollens had rhinitis (p=0.001). Sensitization to profilin was associated with pollen sensitization (p=0.014). 43 patients were sensitized to profilin (40-group A; 3-group B; p=0.006). 21.0% of patients sensitized to pollens, were also sensitized to profilin. 39 patients were sensitized to at least two pollens (p<0.0001). Four profilin and pollen sensitized patients had oral allergy syndrome complaints to melon. This syndrome was related with profilin sensitization (p=0.001). CONCLUSIONS: It is advisable to perform SPT to profilin, particularly in the Inland region, for a better differential diagnosis between cross-reactivity and true sensitization to pollens. The results together with the medical history may support the choice for a specific immunotherapy option.
- Síndrome gato-porco: A propósito de um caso clínicoPublication . Sousa, N; Faria, E; Bartolomé, B; Almeida, E; Segorbe-Luís, A
- Turnip and zucchini: new foods in the latex-fruit syndromePublication . Pereira, C; Tavares, B; Loureiro, G; Lundberg, M; Chieira, C