Browsing by Author "Silva, MR"
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- Adenocarcinoma do pâncreas localmente avançado e metastizado com resposta completa a quimioterapiaPublication . Freire, P; Coelho, AJ; Rodrigues, A; Silva, MR; Lapa, P; Graça, B; Porto, AOs autores apresentam o caso clínico de doente do sexo feminino, 54 anos, raça branca, que recorreu ao médico assistente por dor abdominal associada a manifestações constitucionais. A ecografia revelou massa pancreática e formações nodulares hepáticas compatíveis com lesões secundárias, resultado posteriormente corroborado por tomografia computorizada, que acrescentou critérios de irressecabilidade, nomeadamente invasão dos vasos mesen- téricos e do duodeno. A biopsia ecoguiada obteve material cujo estudo anatomopatológico revelou tratar-se de adeno- carcinoma do pâncreas. Iniciou quimioterapia, verifican- do-se melhoria clínica progressiva. A reavaliação imagio- lógica, após 7 ciclos de tratamento, não detectou a lesão primitiva nem as lesões secundárias, sugerindo resposta completa. Foi mantido esquema regular de quimioterapia, persistindo a remissão 8 meses após a documentação da resposta completa.
- Doença de Hodgkin apresentando-se como síndrome febril indeterminadoPublication . Branco, V; Salvador, MJ; Silva, MR; Martins, P; Carvalho, A; Almiro, E; Porto, A
- Esofagite eosinofílica com aspecto endoscópico peculiarPublication . Freire, P; Portela, F; Rodrigues, A; Silva, MR; Andrade, P; Gouveia, H; Leitão, M
- Hemobilia due to pseudoaneurysm of the cystic arteryPublication . Sousa, HT; Amaro, P; Brito, J; Almeida, J; Silva, MR; Romãozinho, JM; Leitão, M
- Valor prognóstico das proteínas p53, C-erB-2 E Ki67 no carcinoma do ovárioPublication . Frutuoso, C; Silva, MR; Amaral, N; Martins, MI; Oliveira, CF; Oliveira, HMThe prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 67 expression by immunohistochemistry. The results were: age 5.4 +/- 15(22-88); 66% with normal physical activity; 48.2% with residual disease < 2 cm; initial stage--42% and advanced stage--58%. Age, performance status, residual disease and stage were correlated with 2 and 5 years survival. Positive immunostaining: p53--87%, C-erb B-2--51% and Ki67--100%. P53 and C-erb B-2 were associated with residual disease and stage; patients with no C-erbB-2 staining had a significantly better survival. A direct and significant correlation was found between p53 and Ki67 and between C-erb B-2 and p53. We conclude that these markers have a high expression in ovarian carcinoma and p53 and C-er B-2 correlate with stage and residual disease. Although C-erb B-2 was associated with better survival, it was not found to be an independent prognostic factor.