Browsing by Author "Salvador, MJ"
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- Amiloidose secundária e lúpus eritematoso sistémicoPublication . Monteiro, P; Abreu, P; Salvador, MJ; Malcata, ABThe authors report a clinical case of a 57 years old woman with systemic lupus erythematosus diagnosed 25 years before and secondary amyloidosis. Secondary amyloidosis can be associated with inflammatory or infectious chronic diseases, however the association with systemic lupus erythematosus is rare. We discuss the association between the two entities.
- Um caso invulgar de dor generalizada: paramiloidose simulando fibromialgiaPublication . Vaz, C; Couto, M; Duarte, C; Salvador, MJ; Inês, LThe authors report a case of a 52-year old female previously followed at the Outpatient Rheumatology Clinic with the diagnosis of Fibromyalgia (FM). Approximately 2 years after this diagnosis, she presents with a 2nd degree burn in a hand, as a result of thermal hypoesthesia. The patient described hipostesia of the distal upper and lower limbs, incontinence of the anal sphincter and chronic diarrhoea with progressive worsening. The electromiography showed sensory-motor axonal polyneuropathy, chronic, moderate to severe. The muscle and nerve biopsy showed deposition of amyloid substance. The search for TTR Met 30 was positive, confirming the diagnosis of familial amyloidotic polyneuropathy. This is the first reported case of familial amyloidotic polyneuropathy as part of the differential diagnosis of fibromyalgia.
- Condrocalcinose familiar: uma história para dois irmãosPublication . Ambrósio, C; Garcia, J; Salvador, MJ; Malcata, ABCalcium pyrophosphate dihydrate crystal deposition is frequently an asymptomatic disease. However it may cause severe acute attacks of inflammatory arthritis as well as chronic arthropathies. The authors present two case reports of two brothers with chondrocalcinosis and an unusual presentation that mimics rheumatoid arthritis. Special considerations are made about the differences between the familiar and idiopathic forms
- Correlations between virtual touch imaging and quantification absolute skin stiffness, Nailfold capillaroscopy pattern and digital ulcers in systemic sclerosis patientsPublication . Santiago, T; Coutinho, M; Salvador, MJ; Del Galdo, F; Redmond, AC; Pereira da Silva, JA
- Diástase congénita da sínfise púbicaPublication . Vaz, C; Salvador, MJ; Malcata, AB
- Doença de Hodgkin apresentando-se como síndrome febril indeterminadoPublication . Branco, V; Salvador, MJ; Silva, MR; Martins, P; Carvalho, A; Almiro, E; Porto, A
- Doença pulmonar intersticial como manifestação isolada de sindrome anti-sintetasePublication . Monteiro, P; Coutinho, M; Machado, P; Garcia, J; Salvador, MJ; Inês, L; Silva, J; Malcata, ABThe authors report a clinical case of a woman who had a 3 years diagnosis of hipersensitivity pneumonitis based on intersticial lung disease whithout other manifestations. The diagnosis of antisynthetase syndrome was made three years after the initial symptoms upon the onset of systemic manifestations with articular involvement, myositis and determination of anti-PL 7 antibodies. In this syndrome, the isolated pulmonary involvement is rare.
- Elastography: A new imaging method for evaluating scleroderma skinPublication . Santiago, T; Coutinho, M; Salvador, MJ; Del Galdo, F; Redmond, AC; Pereira da Silva, JA
- Evolução de um caso de dermatomiosite amiotróficaPublication . Monteiro, P; Duarte, C; Salvador, MJ; Malcata, ABThe authors report a clinical case of a 41-years-old man with astenia and myalgias maintained for many years without an accurate diagnosis. Amyopathic dermatomyositis was diagnosed based on the presence of typical cutaneous lesions and the absence of myositis. Subsequent evidence of subclinical myositis allowed the diagnosis of hypomyophatic dermatomyositis. Finally, the diagnosis of classical dermatomyositis could be made when the patient presented elevated levels of muscle enzimes. There was a good clinical response to imunossupressor therapy and the patient remains asymptomatic. Differences in the clinical management of amyopathic, hypomyopathic and classic dermatomyositis are discussed.
- Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic reviewPublication . Baptista, R; Serra, S; Martins, R; Teixeira, R; Castro, G; Salvador, MJ; Pereira da Silva, JA; Santos, L; Monteiro, P; Pêgo, MBACKGROUND: Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in patients with SSc with normal resting haemodynamics may anticipate the development of PAH. Exercise echocardiography (ExEcho) has been proposed as a useful technique to identify exercise-induced increases in sPAP, but it is unclear how to clinically interpret these findings. In this systematic review, we summarize the available evidence on the role of exercise echocardiography to estimate exercise-induced elevations in pulmonary and left heart filling pressures in patients with systemic sclerosis. METHODS: We conducted a systematic review of the literature using MEDLINE, Cochrane Library and Web of Knowledge, using the vocabulary terms: ('systemic sclerosis' OR 'scleroderma') AND ('exercise echocardiography') AND ('pulmonary hypertension'). Studies including patients with SSc without a prior diagnosis of PAH, and subjected to exercise echocardiography were included. All searches were limited to English and were augmented by review of bibliographic references from the included studies. The quality of evidence was assessed by the Effective Public Health Practice Project system. RESULTS: We identified 15 studies enrolling 1242 patients, who were mostly middle-aged and female. Several exercise methods were used (cycloergometer, treadmill and Master's two step), with different protocols and positions (supine, semi-supine, upright); definition of a positive test also varied widely. Resting estimated sPAP levels varied from 18 to 35 mm Hg, all in the normal range. The weighted means for estimated sPAP were 22.2 ± 2.9 mmHg at rest and 43.0 ± 4.3 mmHg on exercise; more than half of the studies reported mean exercise sPAP ≥40 mmHg. The assessment of left ventricular diastolic function on peak exercise was reported in a minority of studies; however, when assessed, surrogate variables of left ventricular (LV) diastolic dysfunction were associated with higher sPAP on exercise. CONCLUSIONS: We found very high heterogeneity in the methods, the protocols and the estimated sPAP response to exercise. LV diastolic dysfunction was common and was associated with greater elevation of sPAP on exercise.
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