Browsing by Author "Poiares-Baptista, A"
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- Envolvimento pulmonar subclínico em sarcoidose cutâneaPublication . Robalo-Cordeiro, C; Gonçalo, Margarida; Lima, MA; Mesquita, L; Teixeira, L; Santos-Rosa, M; Azevedo-Bernarda, R; Poiares-Baptista, A; Robalo-Codeiro, AJ
- Experimental studies on the mechanisms of tiaprofenic acid photosensitizationPublication . Figueiredo, A; Fontes-Ribeiro, CA; Gonçalo, Margarida; Poiares-Baptista, A; Teixeira, FRed blood cell lysis and histidine degradation, photosensitized by tiaprofenic acid (TIA), were investigated. Photohaemolysis was markedly enhanced in oxygenated solutions, but was also intense in the presence of nitrogen. Photohaemolysis was inhibited by butylated hydroxyanisole and reduced glutathione, but was unaffected by sodium azide, superoxide dismutase and mannitol. The TIA-induced photo-oxidation of histidine was greatly enhanced in the presence of oxygen and almost completely inhibited in solutions bubbled with nitrogen. Sodium azide, butylated hydroxyanisole and reduced glutathione inhibited the photodegradation of histidine. Phototoxicity to histidine was unaffected by mannitol and superoxide dismutase. The overall results suggest that molecular mechanisms involving free radicals and singlet oxygen are responsible for TIA-photosensitized reactions. These two in vitro models (photohaemolysis and histidine degradation) represent different mechanisms of phototoxicity, but complement one another in the investigation of potential phototoxic substances.
- Familial camptodactylyPublication . Brites, MM; Moreno, AJ; Salgado, M; Poiares-Baptista, ACamptodactyly is a permanent flexion deformity at the interphalangeal joints, usually at the proximal, interphalangeal joints. It is by far most commonly encountered in the little finger, but it can occur in any of the others, and may be associated with a deformity in the little finger or not. It is usually bilateral. It can also appear in the toes, the second toe being the most frequently affected. This deformity can appear in two different situations: it can occur in isolation, or can be a part of a malformative syndrome. It can also be sporadic or be transmitted as an autosomal dominant trait [1, 5, 7, 8]. We report a case of familial camptodactyly not associated with any other disorders: the differential diagnoses included scleroderma and Dupuytren's contracture.
- Hidradenite plantarPublication . Brites, MM; Tellechea, O; Poiares-Baptista, ATender, plantar nodules occurring in pediatric patients can be associated to different clinical entities, despite similar morphological features, therefore dermatopathology is the best technique for the definitive diagnosis. We describe the case for a 12-year-old patient with tender, red nodules on the left sole 3 days in duration, and with moderate functional disability. The onset of the lesions was preceded by low fever, and occurred 6 days after hepatitis B vaccination (Engerix B). The clinical diagnoses were juvenile plantar erythema nodosum, insect bites, pressure urticaria and plantar hidradenitis; Laboratory and radiographic studies, as well as microscopic examination of a skin biopsy specimen, were performed. The lesions resolved spontaneously in about 10 days, without recurrence after a year. A skin biopsy specimen revealed dense neutrophilic infiltrate surrounding and involving eccrine glans with abscess formation at the dermal-hypodermal junction. The diagnosis of idiopathic plantar hidradenitis was made. We discuss this entity, recently described by Stahr et al, and other erythematous plantar nodules in the pediatric age.
- Papular-purpuric "gloves and socks" syndromePublication . Martins, C; Gonçalo, Margarida; Mariano, A; Poiares-Baptista, A
- Photosensitivity to piroxicam: absence of cross-reaction with tenoxicamPublication . Gonçalo, Margarida; Figueiredo, A; Tavares, P; Fontes-Ribeiro, CA; Teixeira, F; Poiares-Baptista, AWe studied 2 groups of patients. One group of 10 patients had a photosensitive eruption to piroxicam. Another group of 24 patients had positive patch test reactions to thimerosal and thiosalicylic acid and had never taken piroxicam or tenoxicam. Patients were patch tested with thimerosal 0.1% pet., thiosalicylic acid 0.1% pet., salicylic acid 2.0% pet., piroxicam 1 and 5% pet. and tenoxicam 1 and 5% pet. Photopatch tests were also performed with piroxicam and tenoxicam. All 10 patients with photosensitivity to piroxicam had positive patch tests to thimerosal and thiosalicylic acid and 9 of them had positive photopatch tests to piroxicam. 20 out of 24 patients with positive patch tests to thiosalicylic acid also had positive photopatch tests to piroxicam. All the patients tested with salicyclic acid were negative. Out of the 29 patients with positive photopatch tests to piroxicam, none reacted to tenoxicam. In countries with a high incidence of contact sensitivity to thimerosal/thiosalicylic acid, the use of piroxicam should be avoided and replaced by tenoxicam, a drug without reported photosensitivity.
- Pigmented photoallergic contact dermatitis from musk ambrettePublication . Gonçalo, S; Gil, J; Gonçalo, Margarida; Poiares-Baptista, A
- Reacções adversas medicamentosas em dermatologiaPublication . Figueiredo, A; Gonçalo, Margarida; Poiares-Baptista, A; Teixeira, F