Browsing by Author "Oliveira, P"
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- Interface entre Demência Frontotemporal e Perturbação Bipolar: a propósito de um caso clínicoPublication . Oliveira, P; Roque, C; Santos, V; Madeira, NA variante comportamental da demência frontotemporal (DFTvc) apresenta-se frequentemente com sintomas psiquiátricos, entre os quais alterações comportamentais e da personalidade. Antes do estabelecimento dos défices cognitivos, a diferenciação entre a DFTvc e outras perturbações psiquiátricas pode ser desafiante. Este artigo apresenta um caso de um episódio maníaco com sintomas psicóticos num doente de 61 anos cujas alterações da personalidade e as dificuldades na realização das tarefas diárias não só se mantiveram, como se agravaram após o tratamento da sintomatologia maniforme e psicótica. Após estudo posterior com avaliação neuropsicológica formal, tomografia computorizada crânio-encefálica (TC-CE) e SPECT cerebral, estabeleceu-se o diagnóstico provável de DFTvc. O presente caso atenta para a possível progressão de formas atípicas e tardias de Perturbação Bipolar (PB) para Demências Frontotemporais. Têm sido propostas várias ligações entre DFT e PB, entre as quais se destacam o envolvimento do gene C9ORF72 em alguns doentes com PB que posteriormente evoluem para demência.
- Interface entre Demência Frontotemporal e Perturbação Bipolar: a propósito de um caso clínico.Publication . Oliveira, P; Roque, C; Santos, V; Madeira, NA variante comportamental da demência frontotemporal (DFTvc) apresenta-se frequentemente com sintomas psiquiátricos, entre os quais alterações comportamentais e da personalidade. Antes do estabelecimento dos défices cognitivos, a diferenciação entre a DFTvc e outras perturbações psiquiátricas pode ser desafiante. Este artigo apresenta um caso de um episódio maníaco com sintomas psicóticos num doente de 61 anos cujas alterações da personalidade e as dificuldades na realização das tarefas diárias não só se mantiveram, como se agravaram após o tratamento da sintomatologia maniforme e psicótica. Após estudo posterior com avaliação neuropsicológica formal, tomografia computorizada crânio-encefálica (TC-CE) e SPECT cerebral, estabeleceu-se o diagnóstico provável de DFTvc. O presente caso atenta para a possível progressão de formas atípicas e tardias de Perturbação Bipolar (PB) para Demências Frontotemporais. Têm sido propostas várias ligações entre DFT e PB, entre as quais se destacam o envolvimento do gene C9ORF72 em alguns doentes com PB que posteriormente evoluem para demência.
- Internamentos Psiquiátricos no Adulto Jovem: Um Estudo Observacional em 2006-2016Publication . Oliveira, P; Ribeiro, J; Morais, S; Santos, V; Madeira, N
- Lithium in Public Drinking Water and Suicide Mortality in Portugal: Initial ApproachPublication . Oliveira, P; Zagalo, J; Madeira, N; Neves, OINTRODUCTION: Lithium can be found naturally in drinking water. There is some evidence that natural levels of lithium in drinking water may have a protective effect on suicide mortality. The aim of this study is to evaluate if higher natural concentrations of lithium in public drinking water are associated with lower local rates of suicide in Portugal. MATERIAL AND METHODS: Suicide standardized mortality ratios at 54 Portuguese municipalities within the 6-year period from 2011 to 2016 was correlated with lithium concentrations in public drinking water and socioeconomic factors using Pearson's correlation coefficients (r) with one-tailed tests. Multivariate regression models were adjusted for well-known socioeconomic factors known to influence suicide mortality in Portugal (population density, average income per capita, unemployment rates and proportion of Roman Catholics). RESULTS: The average lithium level, as evidenced by raw values for 54 municipalities, was 10.88 μg/L (standard deviation = 27.18). There was no statistically significant correlation between lithium levels and suicide standardized mortality ratio (r = 0.001, p-value = 0.996). There was a statistically significant higher suicide standardized mortality ratio for males (p-value = 0.000). When analyzed separately for both sexes, no statistically significant correlation between suicide standardized mortality ratio and lithium levels was found (male r = 0.024, p-value = 0.862; female r = 0.000, p-value = 0.999). No association between suicide standardized mortality ratio and socioeconomic factors was found: population density (r = -0.144, p-value = 0.300), average income per capita (r = -0.112, p-value = 0.418), unemployment rates (r = -0.001, p-value = 0.994), and proportion of Roman Catholics (r =- 0.150, p-value = 0.278). DISCUSSION: Unlike most international studies regarding natural lithium levels and suicide risk, no inverse relation was found in Portugal. Factors such as the country's low suicide rate, confunding suicide risk variables, and unaccounted lithium intake might have influenced these findings. CONCLUSIONS: No association between lithium in public drinking water and suicide rates was found in Portugal.
- Meningitis in a patient with previously undiagnosed Crohn's diseasePublication . Almeida, N; Portela, F; Oliveira, P; Duarte, A; Gregório, C; Gomes, D; Gouveia, H; Leitão, M
- Psychiatric aspects of tumours of the central nervous systemPublication . Madeira, N; Oliveira, P; Santos, T; Albuquerque, E
- Qualidade de vida e vivência da dor crónica nas doenças reumáticasPublication . Oliveira, P; Monteiro, P; Coutinho, M; Salvador, MJ; Costa, ME; Malcata, ABObjectives: To assess differences among health-related quality of life, pain threshold and perception, and passive coping strategies with chronic pain (specifically retreating, worrying, and resting), as well as associations among variables in three groups of rheumatic patients – fibromyalgia (FM), rheumatoid arthritis (RA), and osteoarthritis (OA). Material and methods: 86 participants diagnosed with FM (n = 25), RA (n = 31) and OA (n = 30) completed the following measures: Clinical and Sociodemographic Questionnaire (QSDC), Medical Outcomes Study 36-item Short Form Health Survey (SF-36v2), Pain Coping Inventory (PCI), visual analogic scale (VAS) for pain, and dolorimeter for threshold pain. SPSS software was used to perform statistical analyses. Results: FM patients reported the lowest levels of quality of life and threshold pain, as well as the highest levels of pain perception and passive coping with chronic pain. Associations between variables support that experience with chronic pain is managed more successfully in OA patients, followed by RA patients and, finally, by FM patients. Conclusions: Our findings support the adoption of a biopsychosocial model for assessment and intervention with rheumatic patients, considering specificities associated to each illness.
- SIRT1 and mTOR interplay in bladder cancer: a potential therapeutic targetPublication . Oliveira, P; Silva, AM; Tavares da Silva, E; Jarak, I; Abrantes, M; Botelho, MF; Figueiredo, A; Silva, BM; Pereira, JA; Oliveira, PF; Alves, MG
- Smoking and antidepressants pharmacokinetics: a systematic reviewPublication . Oliveira, P; Ribeiro, J; Donato, H; Madeira, NDespite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes. The aim of this study was to systematically review the evidence of the impact of smoking on new-generation antidepressants with an emphasis on the pharmacokinetic perspective. METHODS: We present a systematic review of clinical trials comparing the serum levels of new-generation antidepressants in smokers and nonsmokers. Data were obtained from MEDLINE/PubMed, Embase, and other sources. Risk of bias was assessed for selection, performance, detection, attrition, and reporting of individual studies. RESULTS: Twenty-one studies met inclusion criteria; seven involved fluvoxamine, two evaluated fluoxetine, sertraline, venlafaxine, duloxetine or mirtazapine, and escitalopram, citalopram, trazodone and bupropion were the subject of a single study. No trials were found involving other common antidepressants such as paroxetine or agomelatine. Serum levels of fluvoxamine, duloxetine, mirtazapine and trazodone were significantly higher in nonsmokers compared with smokers. CONCLUSIONS: There is evidence showing a reduction in the concentration of serum levels of fluvoxamine, duloxetine, mirtazapine and trazodone in smoking patients as compared to nonsmokers. The evidence regarding other commonly used antidepressants is scarce. Nonetheless, smoking status should be considered when choosing an antidepressant treatment, given the risk of pharmacokinetic interactions.