Browsing by Author "Mota, F"
Now showing 1 - 10 of 19
Results Per Page
Sort Options
- Adenocarcinoma arising in adenomyosis: report of an unusual casePublication . Couto, D; Mota, F; Silva, T; Oliveira, CF
- Adenocarcinoma In Situ do Endocolo: a propósito de um caso clínicoPublication . Areia, AL; Frutuoso, C; Dias, I; Mota, F; Oliveira, CF
- Aspiração eco-guiada de lesões quísticas do ovárioPublication . Cabrita, SV; Almeida e Sousa, L; Mota, F; Oliveira, CFIntroduction and Objective: In the last two decades the increased accuracy of ultrasonography has allowed simple ovarian cysts to be reliably identified. As clinical data suggest that simple cystic lesions rarely become malignant, surgical treatment of these cysts may therefore represent overtreatment. Our study aimed to evaluate the results of ultrasound (US) guided aspiration of cystic ovarian lesions performed in our institution in the last ten years.
- Cancer du col de l´utérus: classification et explorations préthérapeutiquesPublication . Oliveira, CF; Mota, FCet article décrit dans ses grandes lignes la classification du cancer du col utérin. Il met l'accent sur l'importance d'un examen clinique pratiqué sous anesthésie et analyse les explorations complémentaires et examens annexes acceptés pour le bilan d'extension du cancer. Les techniques optionnelles susceptibles d'améliorer la classification clinique sont brièvement présentées. Les auteurs soulignent que déterminer le stade d'un cancer du col ne limite en rien les stratégies thérapeutiques disponibles, qui doivent être adaptées à la maladie sur une base individuelle.
- Cervical cancer: pre-therapeutic investigations and clinical staging "versus" surgical stagingPublication . Oliveira, CF; Mota, FAccurate staging of cervical cancer is essential for optimising the results of therapy, because therapy and prognosis vary considerably with the stage. It has been agreed that the staging of a cervical cancer is predominantly a clinical process. Pelvic examination under anaesthesia is indispensable when evaluating the parametria. Cervical cancer generally spreads via local and then regional lymphatics. Lymph node status is crucial in terms of prognosis and therapy of cervical cancer, although it is not incorporated in the FIGO staging classification. The major techniques for evaluating lymph node status include lymphangiography, CT-scan, ultrasonography, MRI and PET. There is a difference in the incidence of pelvic lymph node metastasis comparing stage IB (10-15%), IIA (10-25%) and IIB (25-40%). The obturator group is the most frequently involved. Available studies suggest that the obturator nodes are the primary and sentinel nodes in cervical carcinoma. The preliminary data showed that in early stages, the sentinel node was bilateral in 96% of cases and the sensitivity of the method was 100%. The identification rate was about 80%. The incidence of paraaortic nodes is different according to clinical stages: IB (5-15%), IIB (15-30%) and IIIB (30-45%). The value of surgical staging in the management of cervical cancer is controversial. Pre-treatment surgical staging in patients with cervical cancer has some important benefits: 1. it is the most sensitive and specific of all modalities for the identification of lymph node metastases, 2. it is possible to resect enlarged tumour-containing lymph nodes improving clinical outcome, 3 according to the true extent of the disease, it is possible to modify therapy, 4. it identifies patients with poor prognostic factors, 5. it allows disease downstaging, 6. it increases survival. However, those opposed to the routine use of pre-treatment surgical staging in cervical carcinoma argue that: 1. only a small number of patients can benefit from extended field treatment (± 10%), 2. there is significant morbidity associated with the surgical procedure, 3. there is an increased risk of radiation injury after staging laparotomy, 4. there is the possibility of delaying the initiation of radiotherapy. Laparoscopic staging has been proposed as an alternative to laparotomy with a high sensitivity and specificity. Laparoscopy has several advantages, such as minimal invasion, little adhesion formation and quick recovery of the patient in comparison with laparotomy
- Classification of radical hysterectomy adopted by the Gynecological Cancer Group of the European Organization for Research and Treatment of CancerPublication . Mota, F; Vergote, I; Trimbos, JB; Amant, F; Siddiqui, N; Del Rio, A; Verheijen, R; Zola, PThe Piver classification of radical hysterectomy for the treatment of cervical cancer is outdated and misused. The Surgery Committee of the Gynecological Cancer Group of the European Organization for Research and Treatment of Cancer (EORTC) produced, approved, and adopted a revised classification. It is hoped that at least within the EORTC participating centers, a standardization of procedures is achieved. The clinical indications of the new classification are discussed.
- Endometriose: revisão temáticaPublication . Cabrita, SV; Mota, F; Gil, M; Torgal, I; Oliveira, CF
- Estrogen receptor, progesterone receptor, and bcl-2 are markers with prognostic significance in CIN IIIPublication . Fonseca-Moutinho, JA; Cruz, E; Carvalho, L; Prazeres, HJ; Lacerda, MM; Silva, DP; Mota, F; Oliveira, CFThere are no known biological markers or technologies to predict the natural history of an individual CIN III. The probability of progression is considered greater with the persistence of high-risk human papillomavirus (HPV) infection and age. p53 polymorphism has been associated with cervical carcinogenesis. Hormone-induced cervical cancer is mediated by estrogen receptor (ER) and progesterone receptor (PR). In cervical cancer, increased bcl-2 and Bax immunoreactivity is generally associated with a better prognosis. The purpose of this study was to evaluate the value of HPV 16 and HPV 18 typing and p53 codon polymorphism genotyping by polymerase chain reaction and ER, PR, bcl-2, and Bax expression by immunohistochemistry in predicting the CIN III clinical behavior of CIN III lesions. We studied the expression of these prognostic factors in the CIN III adjacent to squamous cell microinvasive carcinomas of the cervix (MIC) from 29 patients with FIGO stage IA1 cervical cancer and in 25 patients with CIN III and no documented focus of invasion. In the MIC group, only the CIN III was considered at least 2 mm away from the microinvasive complex. The ER, PR, bcl-2, and Bax immunoreactivity was scored as positive (>10% staining cells) and negative (<10% staining cells). No significant difference was observed between MIC and CIN III group concerning HPV infection and p53 polymorphism. The ER, PR, bcl-2, and Bax immunohistochemical expression was stronger and more frequent in the CIN III group. After multivariable analysis, coexpression of ER, PR, and bcl-2 was the only independent factor in defining low risk of progression for CIN III. Our study suggests that coexpression of ER, PR, and bcl-2 may be a useful tool in identifying the CIN III lesions with low risk of progression to cervical cancer
- Fertility Preservation in Cervical cancerPublication . Oliveira, CF; Mota, F
- Gânglio sentinela no cancro da vulva, colo e endométrioPublication . Correia, P; Oliveira, V; Cruz, I; Duarte, H; Lourenço, C; Amaral, N; Mota, F; Silva, T; Lapa, P; Pedroso de Lima, J; Oliveira, CF