Browsing by Author "Lebre, R"
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- Intoxicação aguda por sulfato de cobre: caso clínicoPublication . Lebre, R; Ruiz, V; Leitão, S; Santos, A; Santos, R; Porto, A
- Neoplasia de localização primária desconhecidaPublication . Ferreira, P; Lebre, R; Rodrigues, A; Sá, A; Nascimento-Costa, JM; Porto, ACancers of unknown primary site constitute a heterogeneous group having in common their biological behaviour. We have analysed patients with cancer of unknown primary site admitted to University Hospital of Coimbra/Internal Medicine Service III from 1st January of 1992 to 30th June of 1998. The study included 26 patients corresponding to a prevalence of 2.5% malignant neoplasias; the median age of affected patients was 64 years old with a male-to-female ratio of 4.2:1. The most frequent histological type was well differentiated and moderately well differentiated adenocarcinoma, 46.1% of all cases. Three years global survival rate was 3.9%. The herein-reported prevalence is comparable to that found in recent literature, showing a good diagnostic skill. As expected, the prognosis was poor, revealing the disease's aggressiveness and the lack of efficient therapy in the majority of case.