Publication
Dendritic cells in cord blood transplantation: a review
| dc.contributor.author | Pereira, MI | |
| dc.contributor.author | Paiva, A | |
| dc.date.accessioned | 2011-11-03T14:37:17Z | |
| dc.date.available | 2011-11-03T14:37:17Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells derived from hematopoietic progenitors that bridge the transition between the innate and adaptive immune responses, while maintaining self-tolerance and Th1/Th2 homeostasis, by priming other cells in either an immunogenic or tolerogenic direction. Through their role in both innate and adaptive immunity, DCs play a major part in transplant engraftment and rejection and in graft-versus-host disease (GvHD). Preferentially tolerogenic or immunogenic DC subtypes offer targets for immunotherapy, to optimize transplant success rates and prolong disease-free and overall survival. Cord blood DCs are immature and preferentially tolerogenic, due to maternal-fetal tolerance, leading to better graft acceptance and immune reconstitution and explaining the lower incidence and severity of GvHD in CB transplantation, despite donor-host mismatching. Manipulation of DC maturation and cell loading with tumor-antigens can direct antitumor immunity and target minimal residual disease, as demonstrated for acute myeloid leukemia, optimizing the graft-versus-leukemia effect. | por |
| dc.identifier.citation | Stem Cells Int. 2011;2011:539896. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1101 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Hindawi | por |
| dc.subject | Células Dendríticas | por |
| dc.subject | Transplantação de Células Estaminais | por |
| dc.title | Dendritic cells in cord blood transplantation: a review | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
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