Publication
Pro-inflammatory triggers in childhood obesity: correlation between leptin, adiponectin and high-sensitivity C-reactive protein in a group of obese Portuguese children
| dc.contributor.author | Pires, A | |
| dc.contributor.author | Martins, P | |
| dc.contributor.author | Pereira, AM | |
| dc.contributor.author | Marinho, J | |
| dc.contributor.author | Vaz Silva, P | |
| dc.contributor.author | Marques, M | |
| dc.contributor.author | Castela, E | |
| dc.contributor.author | Sena, C | |
| dc.contributor.author | Seiça, R | |
| dc.date.accessioned | 2016-12-12T16:27:46Z | |
| dc.date.available | 2016-12-12T16:27:46Z | |
| dc.date.issued | 2014-11 | |
| dc.description.abstract | INTRODUCTION: Pediatric obesity is increasingly prevalent in the Portuguese population. Adipocyte dysfunction results in the expression of pro-inflammatory mediators that are responsible for the low-grade inflammatory process that characterizes obesity. OBJECTIVES: The aim of this study was to investigate the relationship between markers of adiposity, inflammation and adipokines in a Portuguese obese pediatric population. METHODS: One hundred and twenty children of both sexes, aged 6-17 years, were included in this study. The control group consisted of 41 healthy normal-weight children. The variables analyzed were age, gender, body mass index, waist circumference, fat mass percentage, high-sensitivity C-reactive protein (hs-CRP), leptin and adiponectin. RESULTS: There were significant differences between controls and obese children for all parameters analyzed. In the obese group, after controlling for age and gender, hs-CRP (p=0.041), adiponectin (p=0.019) and leptin (p<0.001) still showed significant statistical differences. A direct correlation was found between hs-CRP, leptin, body mass index and waist circumference, the strongest being with leptin (r=0.568; p<0.001). This trend remained statistically significant, regardless of gender or pubertal age. CONCLUSIONS: Considering the role of leptin, adiponectin and hs-CRP in the genesis of endothelial dysfunction, they may be used in clinical practice for risk stratification, as well as in the assessment of weight control programs. | pt_PT |
| dc.identifier.citation | Rev Port Cardiol. 2014 Nov;33(11):691-7. | pt_PT |
| dc.identifier.doi | 10.1016/j.repc.2014.04.004 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1999 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Adiponectina | pt_PT |
| dc.subject | Proteína C-Reativa | pt_PT |
| dc.subject | Fígado Gordo Não Alcoólico | pt_PT |
| dc.subject | Obesidade | |
| dc.title | Pro-inflammatory triggers in childhood obesity: correlation between leptin, adiponectin and high-sensitivity C-reactive protein in a group of obese Portuguese children | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 697 | pt_PT |
| oaire.citation.issue | 11 | pt_PT |
| oaire.citation.startPage | 691-7 | pt_PT |
| oaire.citation.volume | 33 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |