Publication
Prognostic Value of Isolated Elevated Troponin I Levels in Patients without Acute Coronary Syndrome Admitted to the Emergency Department
| dc.contributor.author | Domingues, C | |
| dc.contributor.author | Ferreira, MJ | |
| dc.contributor.author | Ferreira, JM | |
| dc.contributor.author | Marinho, AV | |
| dc.contributor.author | Alves, PM | |
| dc.contributor.author | Ferreira, C | |
| dc.contributor.author | Fonseca, I | |
| dc.contributor.author | Gonçalves, L | |
| dc.date.accessioned | 2021-05-20T14:33:47Z | |
| dc.date.available | 2021-05-20T14:33:47Z | |
| dc.date.issued | 2021-05 | |
| dc.description.abstract | Background: Although non-ischemic troponin elevation is frequently seen in patients admitted to the emergency department (ED), consensus regarding its management is lacking. Objectives: This study aimed to characterize patients admitted to the ED with non-ischemic troponin elevation and to identify potential mortality predictors in this population. Methods: This retrospective observational study included ED patients with a positive troponin test result between June and July of 2015. Patients with a clinical diagnosis of acute coronary syndrome (ACS) were excluded. Data on patient demographics and clinical and laboratory variables were extracted from medical records. Follow-up data were obtained for 16 months or until death occurred. The statistical significance level was 5%. Results: Troponin elevation without ACS was found in 153 ED patients. The median (IQR) patient age was 78 (19) years, 80 (52.3%) were female and 59(38.6%) died during follow-up. The median (IQR) follow-up period was 477(316) days. Survivors were significantly younger 76 (24) vs. 84 (13) years; p=0.004) and featured a higher proportion of isolated troponin elevation (without creatine kinase or myoglobin elevation) in two consecutive evaluations: 48 (53.9%) vs. 8 (17.4%), p<0.001. Survivors also presented a lower rate of antiplatelet treatment and same-day hospitalization. In the multivariate logistic regression with adjustment for significant variables in the univariate analysis, isolated troponin elevation in two consecutive evaluations showed a hazard ratio= 0.43 (95%CI 0.17-0.96, p=0.039); hospitalization, previous antiplatelet treatment and age remained independently associated with mortality. Conclusions: Isolated troponin elevation in two consecutive measurements was a strong predictor of survival in ED patients with troponin elevation but without ACS. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Arq Bras Cardiol . 2021 May;116(5):928-937. | pt_PT |
| dc.identifier.doi | 10.36660/abc.20190356 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/2322 | |
| dc.language.iso | por | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Troponina I | pt_PT |
| dc.subject | Serviço de Urgência Hospitalar | pt_PT |
| dc.subject | Síndrome Coronária Aguda | pt_PT |
| dc.subject | Valor Preditivo dos Testes | pt_PT |
| dc.title | Prognostic Value of Isolated Elevated Troponin I Levels in Patients without Acute Coronary Syndrome Admitted to the Emergency Department | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 937 | pt_PT |
| oaire.citation.issue | 5 | pt_PT |
| oaire.citation.startPage | 928-937 | pt_PT |
| oaire.citation.title | Arquivos brasileiros de cardiologia | pt_PT |
| oaire.citation.volume | 116 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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