Repository logo
 
Publication

Osteomielite por Serratia e Doença Granulomatosa Crónica

2011Journal article Open access
Simple item page
dc.contributor.authorCampos, M
dc.contributor.authorRocha, G
dc.contributor.authorCordeiro, A
dc.contributor.authorLemos, S
dc.contributor.authorPaiva, A
dc.contributor.authorSilva, I
dc.contributor.authorFaria, E
dc.date.accessioned2011-12-22T11:06:14Z
dc.date.available2011-12-22T11:06:14Z
dc.date.issued2011
dc.description.abstractChronic Granulomatous Disease (CGD) is a primary immunodeficiency disorder characterized by recurrent purulent infections of the skin, lungs, and reticuloendothelial organs, primarily due to staphylococci, enteric bacteria, fungi, and occasionally mycobacteria. More than two thirds of all cases are X-linked and result from defects in the CYBB gene that encodes the gp91-phox subunit of NADPH oxidase. The authors present a case of a three month old child admitted with a metacarpic steomyelitis by Serratia marcescens. Studies confirmed an abnormal respiratory burst in activated neutrophils and absence of gp91-phox expression on patient and a brother (with previous Nocardia infection). Both hemizygous for a pathogenic mutation detected in exon 3 of CYBB gene (c.252 G>A, p.Ala84Ala), a variant that affects the splicing. At two years of age he is still on prophylaxis with cotrimoxazol and itraconazol, without relevant complications. CGD is rare but must be evocated in cases of uncommon or atypical infections.por
dc.identifier.citationActa Med Port. 2011 May-Jun;24(3):449-52.por
dc.identifier.urihttp://hdl.handle.net/10400.4/1211
dc.language.isoporpor
dc.peerreviewedyespor
dc.publisherCentro Editor Livreiro da Ordem dos Médicospor
dc.subjectCriançapor
dc.subjectDoença Granulomatosa Crónicapor
dc.subjectOsteomielitepor
dc.titleOsteomielite por Serratia e Doença Granulomatosa Crónicapor
dc.title.alternativeSerratia osteomyelitis and chronic granulomatous diseasepor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
acta med port.pdf
Size:
221.62 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
acta med port.pdf
Size:
221.62 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ALER - Artigos