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Circulating cell-free DNA levels in Portuguese patients with psoriasis vulgaris according to severity and therapy.

2014Journal article Open access
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dc.contributor.authorCoimbra, S
dc.contributor.authorCatarino, C
dc.contributor.authorCosta, E
dc.contributor.authorOliveira, H
dc.contributor.authorFigueiredo, A
dc.contributor.authorRocha-Pereira, P
dc.contributor.authorSantos-Silva, A
dc.date.accessioned2014-07-03T10:50:59Z
dc.date.available2014-07-03T10:50:59Z
dc.date.issued2014
dc.description.abstractassociated with inflammation. OBJECTIVES: We aimed to understand the relation of CFD levels with psoriasis severity, defined by the Psoriasis Area and Severity Index (PASI), with inflammation and with psoriasis therapy. METHODS: Forty-six patients with psoriasis vulgaris were evaluated before (T0) and after 12 weeks (T12) of treatment with narrowband ultraviolet light B (NB-UVB; n = 17), psoralen plus UVA (PUVA; n = 20) or topical therapy (n = 9). We evaluated interleukin (IL)-6 and circulating CFD levels. RESULTS: Compared with controls, at T0, patients presented significantly higher levels of circulating CFD. CFD presented a significant positive correlation with IL-6 and a trend towards a positive correlation with PASI. Multiple linear regression analysis identified IL-6 as an independent variable associated with CFD circulating levels. As shown by the PASI score, a trend towards higher values of CFD was observed in the severe psoriasis forms; moderate and severe psoriasis presented also significantly higher CFD values, compared with control. Both NB-UVB and PUVA treatments significantly decreased the levels of CFD. CONCLUSIONS: Patients with psoriasis, at the active stage of the disease, presented an increased inflammation associated with raised circulating CFD levels, which seem to be linked to psoriasis severity. Both NB-UVB and PUVA, anti-inflammatory therapies, were effective in decreasing CFD values. We propose that the evaluation of circulating CFD may provide a new biomarker to monitor psoriasis, its severity and its treatment.por
dc.identifier.citationBr J Dermatol. 2014;170(4):939-42.por
dc.identifier.urihttp://hdl.handle.net/10400.4/1709
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectPsoríasepor
dc.titleCirculating cell-free DNA levels in Portuguese patients with psoriasis vulgaris according to severity and therapy.por
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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