Publication
Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet.
| dc.contributor.author | Sena, CM | |
| dc.contributor.author | Louro, T | |
| dc.contributor.author | Matafome, P | |
| dc.contributor.author | Nunes, E | |
| dc.contributor.author | Monteiro, P | |
| dc.contributor.author | Seiça, R | |
| dc.date.accessioned | 2011-10-14T14:47:18Z | |
| dc.date.available | 2011-10-14T14:47:18Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial function in Goto-Kakizaki rats (GK), an animal model of type 2 diabetes fed an atherogenic diet for 4 months. We evaluated the influence of gliclazide on both metabolic and oxidative status and NO-mediated vasodilation. GKAD rats showed increased oxidative stress and impaired endothelium-dependent vasodilation. GKAD rats treated with gliclazide showed increased sensitivity to NO-mediated vasodilation, a significant decrease in fasting glycemia and insulinemia, and a significant decrease in systemic oxidative stress. In conclusion, our results suggest that gliclazide treatment improves NO-mediated vasodilation in diabetic GK rats with dyslipidemia probably due to its antioxidant effects, although we cannot rule out substantial benefits due to a reduction in fasting blood glucose. The availability of a compound that simultaneously decreases hyperglycemia, hyperinsulinemia, and inhibits oxidative stress is a promising therapeutic candidate for the prevention of vascular complications of diabetes. | por |
| dc.identifier.citation | Physiol Res. 2009;58(2):203-9. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1074 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Biomed Central | por |
| dc.subject | Angiopatias Diabéticas | por |
| dc.subject | Antioxidantes | por |
| dc.subject | Diabetes Mellitus | por |
| dc.subject | Gliclazida | por |
| dc.subject | Ratos | por |
| dc.title | Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet. | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |