Publication
Aortic Valve Disease and Vascular Mechanics: Two-Dimensional Speckle Tracking Echocardiographic Analysis
| dc.contributor.author | Leite, L | |
| dc.contributor.author | Teixeira, R | |
| dc.contributor.author | Oliveira-Santos, M | |
| dc.contributor.author | Barbosa, A | |
| dc.contributor.author | Martins, R | |
| dc.contributor.author | Castro, G | |
| dc.contributor.author | Gonçalves, L | |
| dc.contributor.author | Pego, M | |
| dc.date.accessioned | 2017-09-01T11:29:06Z | |
| dc.date.available | 2017-09-01T11:29:06Z | |
| dc.date.issued | 2016-08 | |
| dc.description.abstract | PURPOSE: Degenerative aortic valve disease (AVD) is a complex disorder that goes beyond valve itself, also undermining aortic wall. We aimed to assess the ascending aortic mechanics with two-dimensional speckle tracking echocardiography (2DSTE) in patients with aortic regurgitation (AR) and hypothesized a relationship with degree of AR. Aortic mechanics were then compared with those of similarly studied healthy controls and patients with aortic stenosis (AS); finally, we aimed to assess the prognostic significance of vascular mechanics in AVD. METHODS: Overall, 73 patients with moderate-to-severe AR and 22 healthy subjects were enrolled, alongside a previously examined cohort (N = 45) with moderate-to-severe AS. Global circumferential ascending aortic strain (CAAS) and strain rate (CAASR) served as indices of aortic deformation; corrected CAAS was calculated as CAAS/pulse pressure (PP). Median clinical follow-up was 438 days. RESULTS: In patients with severe (vs. moderate) AR, CAASR (1.53 ± 0.29/sec vs. 1.90 ± 0.62/sec, P < 0.05) and corrected CAAS (0.14 ± 0.06%/mmHg vs. 0.19 ± 0.08%/mmHg, P < 0.05) were significantly lower, whereas CAAS did not differ significantly. Measurers of aortic mechanics (CAAS, corrected CAAS, CAASR) differed significantly (all P < 0.01) in patients with AS and AR and in healthy subjects, with lower values seen in patients with AS. In follow-up, survival rate of AVD patients with baseline CAASR >0.88/sec was significantly higher (log rank, 97.4% vs. 73.0%; P = 0.03). CONCLUSIONS: Quantitative measures of aortic mechanics were lower for AS patients, suggesting a more significant derangement of aortic elastic properties. In the context of AVD, vascular mechanics assessment proved useful in gauging clinical prognosis. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Echocardiography. 2016 Aug;33(8):1121-30. | pt_PT |
| dc.identifier.doi | 10.1111/echo.13236 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/2093 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Insuficiência da Válvula Aórtica | pt_PT |
| dc.subject | Estenose da Válvula Aórtica | pt_PT |
| dc.subject | Ecocardiografia | pt_PT |
| dc.subject | Técnicas de Imagem por Elasticidade | pt_PT |
| dc.title | Aortic Valve Disease and Vascular Mechanics: Two-Dimensional Speckle Tracking Echocardiographic Analysis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1130 | pt_PT |
| oaire.citation.issue | 8 | pt_PT |
| oaire.citation.startPage | 1121-30 | pt_PT |
| oaire.citation.volume | 33 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |