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Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Study

dc.contributor.authorDiaz, SO
dc.contributor.authorPinto, JJ
dc.contributor.authorBarros, AS
dc.contributor.authorMorais, E
dc.contributor.authorDuarte, D
dc.contributor.authorNegrão, F
dc.contributor.authorPita, C
dc.contributor.authorAlmeida, MC
dc.contributor.authorCarreira, IM
dc.contributor.authorSpraul, M
dc.contributor.authorGil, AM
dc.date.accessioned2017-09-01T13:20:45Z
dc.date.available2017-09-01T13:20:45Z
dc.date.issued2016-01-04
dc.description.abstractThis work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consideration in unmatched subject groups. Premature newborns are, however, characterized by a stronger signature of varying metabolites, suggestive of disturbances in nucleotide metabolism, lung surfactants biosynthesis and renal function, along with enhancement of tricarboxylic acid (TCA) cycle activity, fatty acids oxidation, and oxidative stress. Comparison with other abnormal conditions (respiratory depression episode, large for gestational age, malformations, jaundice and premature rupture of membranes) reveals that such signature seems to be largely specific of preterm newborns, showing that NMR metabolomics can retrieve particular disorder effects, as well as general stress effects. These results provide valuable novel information on the metabolic impact of prematurity, contributing to the better understanding of its effects on the newborn's state of health.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Proteome Res. 2016 Jan 4;15(1):311-25.pt_PT
dc.identifier.doi10.1021/acs.jproteome.5b00977pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2097
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectNascimento Prematuropt_PT
dc.subjectSíndrome do Desconforto Respiratório do Recém-Nascidopt_PT
dc.subjectUrinálisept_PT
dc.subjectBiomarcadorespt_PT
dc.titleNewborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage325pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage311-25pt_PT
oaire.citation.volume15pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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