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Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis

2002-05-14Journal article Open access
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dc.contributor.authorTralhao, JG
dc.contributor.authorRoudier, J
dc.contributor.authorMorosan, S
dc.contributor.authorGiannini, C
dc.contributor.authorTu, H
dc.contributor.authorGoulenok, C
dc.contributor.authorCarnot, F
dc.contributor.authorZavala, F
dc.contributor.authorJoulin, V
dc.contributor.authorKremsdorf, D
dc.contributor.authorBréchot, C
dc.date.accessioned2018-11-28T15:06:57Z
dc.date.available2018-11-28T15:06:57Z
dc.date.issued2002-05-14
dc.description.abstractThe role of the hepatitis B virus X protein (HBx) in the pathogenesis of hepatitis B virus (HBV) infection remains unclear. HBx exhibits pleiotropic biological effects, whose in vivo relevance is a matter for debate. In the present report, we have used a combination of HBx-expressing transgenic mice and liver cell transplantation to investigate the in vivo impact of HBx expression on liver cell proliferation and viability in a regenerative context. We show that moderate HBx expression inhibits liver regeneration after partial hepatectomy in HBx-expressing transgenic mice. We also demonstrate that the transplantation of HBx-expressing liver cells, isolated from HBx transgenic mice, is sufficient to inhibit overall recipient liver regeneration after partial hepatectomy. Moreover, the injection of serum samples drawn from HBx-expressing transgenic mice mimicked the inhibitory effect of HBx on liver regeneration. Finally, the incubation of primary rat hepatocytes with the supernatant of HBx-expressing liver cells inhibits cellular DNA synthesis. Taken together, our results demonstrate a paracrine inhibitory effect of HBx on liver cell proliferation and lead us to propose HBV as one of the few viruses implicated in human cancer which act, at least in part, through paracrine biological pathways.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationProc Natl Acad Sci U S A. 2002 May 14;99(10):6991-6.pt_PT
dc.identifier.doi10.1073/pnas.092657699pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2185
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectRatospt_PT
dc.subjectVírus da Hepatite Bpt_PT
dc.subjectFígado/metabolismopt_PT
dc.subjectComunicação Parácrinapt_PT
dc.subjectTransativadorespt_PT
dc.subjectMalept_PT
dc.titleParacrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6996pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage6991-6pt_PT
oaire.citation.volume99pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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