Publication
Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability
| dc.contributor.author | Carrapita, J | |
| dc.contributor.author | Abrantes, AM | |
| dc.contributor.author | Campelos, S | |
| dc.contributor.author | Gonçalves, AC | |
| dc.contributor.author | Cardoso, D | |
| dc.contributor.author | Sarmento-Ribeiro, AB | |
| dc.contributor.author | Rocha, C | |
| dc.contributor.author | Santos, JN | |
| dc.contributor.author | Botelho, MF | |
| dc.contributor.author | Tralhão, JG | |
| dc.contributor.author | Farges, O | |
| dc.contributor.author | Barbosa, JM | |
| dc.date.accessioned | 2016-10-26T14:05:35Z | |
| dc.date.available | 2016-10-26T14:05:35Z | |
| dc.date.issued | 2016-10-11 | |
| dc.description.abstract | It was reported that prevention of acute portal overpressure in small-for-size livers by inflow modulation results in a better postoperative outcome. The aim is to investigate the impact of portal blood flow reduction by splenic artery ligation after major hepatectomy in a murine model. Forty-eight rats were subjected to an 85% hepatectomy or 85% hepatectomy and splenic artery ligation. Both groups were evaluated at 24, 48, 72 and 120 post-operative hours: liver function, regeneration and viability. All methods and experiments were carried out in accordance with Coimbra University guidelines. Splenic artery ligation produces viability increase after 24 h, induces a relative decrease in oxidative stress during the first 48 hours, allows antioxidant capacity increment after 24 h, which is reflected in a decrease of half-time normalized liver curve at 48 h and at 72 h and in an increase of mitotic index between 48 h and 72 h. Splenic artery ligation combined with 85% hepatectomy in a murine model, allows portal inflow modulation, promoting an increase in hepatocellular viability and regeneration, without impairing the function, probably by inducing a less marked elevation of oxidative stress at first 48 hours. | pt_PT |
| dc.identifier.citation | Sci Rep. 2016 Oct 11;6:34731. | pt_PT |
| dc.identifier.doi | 10.1038/srep34731 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1961 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Artéria Esplénica | pt_PT |
| dc.subject | Hepatectomia | pt_PT |
| dc.title | Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 34731 | pt_PT |
| oaire.citation.volume | 6 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |