Repository logo
 
Publication

Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients

dc.contributor.authorVaz, CC
dc.contributor.authorCouto, M
dc.contributor.authorMedeiros, D
dc.contributor.authorMiranda, L
dc.contributor.authorCosta, J
dc.contributor.authorNero, P
dc.contributor.authorBarros, R
dc.contributor.authorSantos, MJ
dc.contributor.authorSousa, E
dc.contributor.authorBarcelos, A
dc.contributor.authorInês, L
dc.date.accessioned2009-05-07T13:48:56Z
dc.date.available2009-05-07T13:48:56Z
dc.date.issued2009
dc.description.abstractThe purpose of this study was to characterize the clinical and serological features of a large cohort of patients with antinuclear antibody (ANA) positive undifferentiated connective tissue disease (UCTD). Consecutive patients with UCTD, followed up at the Rheumatology Clinic of the participating centers, were included. Data from these patients were obtained by clinical evaluation and chart review. All patients were diagnosed as having UCTD on basis of the following criteria: positive ANA plus at least one clinical feature of connective tissue disease, but not fulfilling classification criteria for any differentiated connective tissue disease. One hundred eighty-four patients were studied (female patients-94.5%; mean age at time of evaluation-47 years). The most prevalent manifestations were arthralgia (66%), arthritis (32%), Raynaud's phenomenon (30%), sicca symptoms (30%), and leukopenia (19%). The prevalence of ANA was 100%, anti-SSA 20%, anti-dsDNA 14%, and anti-SSB 7%. Patients with anti-dsDNA/anti-Sm, anticentromere/anti-Scl70, or anti-SSA/anti-SSB antibodies more frequently presented a set of manifestations close to systemic lupus erythematosus (SLE), systemic sclerosis, or Sjögren syndrome, respectively. We analyze a large cohort of UCTD. Seventy-two percent of these UCTD patients present lupus-, scleroderma-, or Sjögren-like features but do not fulfill classification criteria and mostly present a mild disease.en
dc.identifier.citationClin Rheumatol. 2009 Apr 24.en
dc.identifier.urihttp://hdl.handle.net/10400.4/500
dc.language.isoengen
dc.publisherSpringeren
dc.rights.uriopenAccessen
dc.subjectDoenças do Tecido Conjuntivoen
dc.titleUndifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patientsen
dc.typejournal article
dspace.entity.typePublication
rcaap.typearticleen

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Artigo Clin Rheumatol.pdf
Size:
137.15 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.8 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections