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CA-125 AUC as a predictor for epithelial ovarian cancer relapse

dc.contributor.authorMano, A
dc.contributor.authorFalcão, A
dc.contributor.authorGodinho, I
dc.contributor.authorSantos, J
dc.contributor.authorLeitão, F
dc.contributor.authorOliveira, CF
dc.contributor.authorCaramona, M
dc.date.accessioned2009-03-25T15:43:47Z
dc.date.available2009-03-25T15:43:47Z
dc.date.issued2008
dc.description.abstractPURPOSE: The aim of the present work was to evaluate the usefulness of CA-125 normalized in time area under the curve (CA-125 AUC) to signalise epithelial ovarian cancer relapse. PATIENTS AND METHODS: Data from a hundred and eleven patients were submitted to two different approaches based on CA-125 AUC increase values to predict patient relapse. In Criterion A total CA-125 AUC normalized in time value (AUC(i)) was compared with the immediately previous one (AUC(i-1)) using the formulae AUC(i) > or = F * AUC(i-1) (several F values were tested) to find the appropriate close related increment associated to patient relapse. In Criterion B total CA-125 AUC normalised in time was calculated and several cut-off values were correlated with patient relapse prediction capacity. RESULTS: In Criterion A the best accuracy was achieved with a factor (F) of 1.25 (increment of 25% from the previous status), while in Criterion B the best accuracies were achieved with cut-offs of 25, 50, 75 and 100 IU/mL. The mean lead time to relapse achieved with Criterion A was 181 days, while with Criterion B they were, respectively, 131, 111, 63 and 11 days. CONCLUSION: Based on our results we believe that conjugation and sequential application of both criteria in patient relapse detection should be highly advisable. CA-125 AUC rapid burst in asymptomatic patients should be firstly evaluated using Criterion A with a high accuracy (0.85) and with a substantial mean lead time to relapse (181 days). If a negative answer was obtained then Criterion B should performed to confirm the absence of relapse.en
dc.identifier.citationCancer Biomark. 2008;4(2):73-81en
dc.identifier.urihttp://hdl.handle.net/10400.4/476
dc.language.isoengen
dc.publisherIOS Pressen
dc.rights.uriopenAccessen
dc.subjectNeoplasias do Ovárioen
dc.subjectMarcadores Tumorais Biológicosen
dc.subjectAntigénio CA-125en
dc.titleCA-125 AUC as a predictor for epithelial ovarian cancer relapseen
dc.typejournal article
dspace.entity.typePublication
rcaap.typearticleen

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