Publication
CA-125 AUC as a predictor for epithelial ovarian cancer relapse
dc.contributor.author | Mano, A | |
dc.contributor.author | Falcão, A | |
dc.contributor.author | Godinho, I | |
dc.contributor.author | Santos, J | |
dc.contributor.author | Leitão, F | |
dc.contributor.author | Oliveira, CF | |
dc.contributor.author | Caramona, M | |
dc.date.accessioned | 2009-03-25T15:43:47Z | |
dc.date.available | 2009-03-25T15:43:47Z | |
dc.date.issued | 2008 | |
dc.description.abstract | PURPOSE: The aim of the present work was to evaluate the usefulness of CA-125 normalized in time area under the curve (CA-125 AUC) to signalise epithelial ovarian cancer relapse. PATIENTS AND METHODS: Data from a hundred and eleven patients were submitted to two different approaches based on CA-125 AUC increase values to predict patient relapse. In Criterion A total CA-125 AUC normalized in time value (AUC(i)) was compared with the immediately previous one (AUC(i-1)) using the formulae AUC(i) > or = F * AUC(i-1) (several F values were tested) to find the appropriate close related increment associated to patient relapse. In Criterion B total CA-125 AUC normalised in time was calculated and several cut-off values were correlated with patient relapse prediction capacity. RESULTS: In Criterion A the best accuracy was achieved with a factor (F) of 1.25 (increment of 25% from the previous status), while in Criterion B the best accuracies were achieved with cut-offs of 25, 50, 75 and 100 IU/mL. The mean lead time to relapse achieved with Criterion A was 181 days, while with Criterion B they were, respectively, 131, 111, 63 and 11 days. CONCLUSION: Based on our results we believe that conjugation and sequential application of both criteria in patient relapse detection should be highly advisable. CA-125 AUC rapid burst in asymptomatic patients should be firstly evaluated using Criterion A with a high accuracy (0.85) and with a substantial mean lead time to relapse (181 days). If a negative answer was obtained then Criterion B should performed to confirm the absence of relapse. | en |
dc.identifier.citation | Cancer Biomark. 2008;4(2):73-81 | en |
dc.identifier.uri | http://hdl.handle.net/10400.4/476 | |
dc.language.iso | eng | en |
dc.publisher | IOS Press | en |
dc.rights.uri | openAccess | en |
dc.subject | Neoplasias do Ovário | en |
dc.subject | Marcadores Tumorais Biológicos | en |
dc.subject | Antigénio CA-125 | en |
dc.title | CA-125 AUC as a predictor for epithelial ovarian cancer relapse | en |
dc.type | journal article | |
dspace.entity.type | Publication | |
rcaap.type | article | en |