Publication
Simultaneous renal transplantation and native nephrectomy in patients with autosomal-dominant polycystic kidney disease
dc.contributor.author | Nunes, P | |
dc.contributor.author | Mota, A | |
dc.contributor.author | Alves, R | |
dc.contributor.author | Figueiredo, A | |
dc.contributor.author | Parada, B | |
dc.contributor.author | Macário, F | |
dc.contributor.author | Rolo, F | |
dc.date.accessioned | 2008-12-19T16:33:21Z | |
dc.date.available | 2008-12-19T16:33:21Z | |
dc.date.issued | 2007 | |
dc.description.abstract | Our objective was to study the influence on transplant outcome of unilateral native nephrectomy of massively enlarged kidneys at the time of renal transplantation among patients with end-stage renal disease owing to autosomal-dominant polycystic kidney disease (ADPKD). PATIENTS AND METHODS: We studied 159 renal transplants in patients with ADPKD divided into two groups according to the need to perform a unilateral native nephrectomy owing to enlarged kidneys (N+; n = 143) versus those not (N0; n = 16) needing this procedure. Parameters related to the donors, grafts, recipients, and operative data were correlated with short- and long-term outcomes. The groups were homogeneous in terms of recipient and donor ages, genders, HLA compatibilities, and length of pretransplant dialysis. RESULTS: When no nephrectomy was needed surgery length was shorter (N0, 3.01 vs. N+, 4.23 hours; P < .001), less intraoperative crystalloids were infused (N0, 1.84 vs. N+, 2.76 L; P < .001), and less plasma (N0, 2.07 vs. N+, 2.93 U; P < .05), or blood (N0, 1.05 vs. N+, 1.81 U; P < .05) transfusions were required. Hospital stay was similar (N0, 12.70 vs N+, 16.50 days; P not significant [NS]). There was only one urologic complication in the nephrectomy group. There were no differences (P = NS) in rates of delayed graft function (N0, 19.9%; N+, 12.5%), acute rejections (N0, 25.5%; N0, 33.3%), chronic allograft dysfunction (N0, 15.8%; N+, 28.6%). Graft function at 1 month as well as 1 and 5 years were comparable. Patient and graft survivals were similar at 1 and 5 years. There were no differences in the causes of graft loss or patient death. CONCLUSION: In patients with ADPKD native nephrectomy of massively enlarged kidneys may be safely performed during the transplant procedure with no repercussions on the length of hospital stay, graft short- and long-term function and patient survival. However the procedure eads to a longer operative time and greater need for fluids and blood products. | en |
dc.identifier.citation | Transplant Proc. 2007 Oct;39(8):2483-5 | en |
dc.identifier.uri | http://hdl.handle.net/10400.4/363 | |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.subject | Nefrectomia | en |
dc.subject | Transplantação de Rim | en |
dc.subject | Doença Renal Poliquística Autossómica Dominante | en |
dc.title | Simultaneous renal transplantation and native nephrectomy in patients with autosomal-dominant polycystic kidney disease | en |
dc.type | journal article | |
dspace.entity.type | Publication | |
rcaap.rights | openAccess | |
rcaap.type | article | en |