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Left ventricular end diastolic pressure and acute coronary syndromes

2011Journal article Open access
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dc.contributor.authorTeixeira, R
dc.contributor.authorLourenço, C
dc.contributor.authorBaptista, R
dc.contributor.authorJorge, E
dc.contributor.authorMendes, P
dc.contributor.authorSaraiva, F
dc.contributor.authorMonteiro, S
dc.contributor.authorMonteiro, P
dc.contributor.authorFerreira, MJ
dc.contributor.authorFreitas, M
dc.contributor.authorProvidência, LA
dc.date.accessioned2011-11-03T15:34:28Z
dc.date.available2011-11-03T15:34:28Z
dc.date.issued2011
dc.description.abstractBACKGROUND: Data is lacking in the literature regarding the prognostic impact of left ventricular-end diastolic pressure (LVEDP) across acute coronary syndromes (ACS). OBJECTIVE: To assess LVEDP and its prognostic implications in ACS patients. METHODS: Prospective, longitudinal and continuous study of 1329 ACS patients from a single center between 2004 and 2006. Diastolic function was determined by LVEDP. Population was divided in two groups: A - LVEDP < 26.5 mmHg (n = 449); group B - LVEDP > 26.5 mmHg (n = 226). RESULTS: There were no significant differences between groups with respect to risk factors for cardiovascular disease, medical history and medical therapy during admission. In group A, patients with non-ST elevation ACS were more frequent, as well as normal coronary angiograms. In-hospital mortality was similar between groups, but one-year survival was higher in group A patients (96.9 vs 91.2%, log rank p = 0.002). On a multivariate Cox regression model, a LVEDP > 26.5 mmHg (HR 2.45, 95%CI 1.05 - 5.74) remained an independent predictor for one-year mortality, when adjusted for age, LV systolic ejection fraction, ST elevation ACS, peak troponin, admission glycemia, and diuretics at 24 hours. Also, a LVEDP > 26.5 mmHg was an independent predictor for a future readmission due to congestive HF (HR 6.65 95%CI 1.74 - 25.5). CONCLUSION: In our selected population, LVEDP had a significant prognostic influence.por
dc.identifier.citationArq Bras Cardiol. 2011 Aug;97(2):100-110.por
dc.identifier.urihttp://hdl.handle.net/10400.4/1106
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectDisfunção Ventricular Esquerdapor
dc.subjectSíndrome Coronária Agudapor
dc.titleLeft ventricular end diastolic pressure and acute coronary syndromespor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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