Publication
Cardiac resynchronization therapy is effective even in elderly patients with comorbidities
| dc.contributor.author | António, N | |
| dc.contributor.author | Lourenço, C | |
| dc.contributor.author | Teixeira, R | |
| dc.contributor.author | Saraiva, F | |
| dc.contributor.author | Coelho, L | |
| dc.contributor.author | Ventura, M | |
| dc.contributor.author | Cristovão, J | |
| dc.contributor.author | Elvas, L | |
| dc.contributor.author | Gonçalves, L | |
| dc.contributor.author | Providência, LA | |
| dc.date.accessioned | 2012-01-11T18:31:08Z | |
| dc.date.available | 2012-01-11T18:31:08Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | PURPOSE: The purpose of this study was to compare the effects of cardiac resynchronization therapy (CRT) in elderly patients (> or =65 years) with younger patients and to assess the impact of comorbidities in CRT remodeling response. METHODS: This is a prospective study of 87 consecutive patients scheduled for CRT who underwent clinical and echocardiographic evaluation before and 6 months after CRT. A reduction in left ventricular end-systolic volume (LVESV) > or =15% after CRT defined remodeling responders, and a reduction of at least one New York Heart Association class defined clinical responders. Multivariate analysis was used to identify independent predictors of non-response to CRT in terms of reverse remodeling. RESULTS: The mean age was 62 +/- 11 years, with 36 elderly patients (41%). The baseline QRS duration was 145 +/- 32 ms. After CRT, there were significant and similar improvements of left ventricular (LV) ejection fraction, LVESV, LV dP/dt, and mitral regurgitation jet area (JA) between elderly (> or =65 years) and younger (<65 years) patients. The number of clinical and remodeling responders was comparable, and we found no significant differences in unplanned cardiac hospitalizations at 6 months between groups. Independent predictors of lack of remodeling response to CRT were QRS duration <120 ms, LV diastolic diameter >74 mm, and JA >10 cm(2) before CRT, but not comorbidities. CONCLUSION: This work suggests that being elderly is not an impediment to CRT success even in the presence of comorbidities. | por |
| dc.identifier.citation | J Interv Card Electrophysiol. 2010;27(1):61-8. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1245 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.subject | Insuficiência Cardíaca | por |
| dc.subject | Fibrilhação Auricular | por |
| dc.subject | Idoso | |
| dc.title | Cardiac resynchronization therapy is effective even in elderly patients with comorbidities | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |