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Sequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiography

2016Journal article Open access
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dc.contributor.authorMarques, JP
dc.contributor.authorCosta, JF
dc.contributor.authorMarques, M
dc.contributor.authorCachulo, ML
dc.contributor.authorFigueira, J
dc.contributor.authorSilva, R
dc.date.accessioned2016-10-26T14:28:15Z
dc.date.available2016-10-26T14:28:15Z
dc.date.issued2016
dc.description.abstractPURPOSE: To assess and describe sequential morphological changes in the choroidal neovascularization (CNV) net using optical coherence tomography angiography (OCTA) in patients undergoing treatment with intravitreal antivascular endothelial growth factor (VEGF). METHODS: Prospective cohort study. OCTA was performed sequentially: before (t0), 1 h (t1), 1 week (t2) and 1 month after the injection (t3), using Avanti RTVue XR equipped with the AngioVue® software (Optovue, Calif., USA). All images were classified by two independent graders. RESULTS: Ten eyes of 10 patients, with a mean age of 72.4 ± 10.5 years, were included. CNV morphology was described as tree-like in 5 eyes, glomerular in 1 and fragmented in 4. A fibrovascular capsule surrounding the CNV net was found in 4 eyes and a feeder trunk was noticed in 6. No changes were observed at t1. Loss of peripheral capillaries, vessel fragmentation and decreased vessel density were evident in 8 eyes at t2. The CNV capillary density and the peripheral anastomosis increased in all of these at t3. Two eyes remained unchanged through the whole length of follow-up. CONCLUSIONS: Significant changes in the CNV net can be observable in OCTA at least 1 week after intravitreal anti-VEGF. The safety of frequent examinations may provide a method of gauging treatment effects.pt_PT
dc.identifier.citationOphthalmic Res. 2016;55(3):145-51.pt_PT
dc.identifier.doi10.1159/000442671pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/1964
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAngiofluoresceinografiapt_PT
dc.subjectInjecções Intravítreaspt_PT
dc.subjectNeovascularização da Coróidept_PT
dc.subjectTomografia de Coerência Ópticapt_PT
dc.subjectFactor A de Crescimento do Endotélio Vascularpt_PT
dc.titleSequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiographypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage151pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage145-51pt_PT
oaire.citation.volume55pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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