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Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice

dc.contributor.authorSidorkiewicz, M
dc.contributor.authorJais, JP
dc.contributor.authorTralhao, JG
dc.contributor.authorMorosan, S
dc.contributor.authorGiannini, C
dc.contributor.authorBrezillon, N
dc.contributor.authorSoussan, P
dc.contributor.authorDelpuech, O
dc.contributor.authorKremsdorf, D
dc.date.accessioned2018-11-28T15:45:43Z
dc.date.available2018-11-28T15:45:43Z
dc.date.issued2008-01-28
dc.description.abstractAIM: To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice. METHODS: Microarray technology was performed on liver tissue obtained from 4 control (LacZ) and 4 transgenic mice (HBx-LacZ), 48 h after partial hepatectomy. The significance of the normalized log-ratios was assessed for each gene, using robust t-tests under an empirical Bayes approach. Microarray hybridization data was verified on selected genes by quantitative PCR. RESULTS: The comparison of gene expression patterns showed a consistent modulation of the expression of 26 genes, most of which are implicated in liver regeneration. Up-regulated genes included DNA repair proteins (Rad-52, MSH6) and transmembrane proteins (syndecan 4, tetraspanin), while down-regulated genes were connected to the regulation of transcription (histone deacetylase, Zfp90, MyoD1) and were involved in the cholesterol metabolic pathway and isoprenoid biosynthesis (farnesyl diphosphate synthase, Cyp7b1, geranylgeranyl diphosphate synthase, SAA3). CONCLUSION: Our results provide a novel insight into the biological activities of HBx, implicated in the inhibition of liver regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWorld J Gastroenterol. 2008 Jan 28;14(4):574-81.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2190
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHepatite B Crónicapt_PT
dc.subjectRegeneração Hepáticapt_PT
dc.subjectAnálise de Sequência com Séries de Oligonucleotídeospt_PT
dc.subjectTransativadorespt_PT
dc.titleGene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage574-81pt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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