Publication
Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trial
| dc.contributor.author | Iagaru, A | |
| dc.contributor.author | Mittra, E | |
| dc.contributor.author | Mosci, C | |
| dc.contributor.author | Dick, DW | |
| dc.contributor.author | Sathekge, M | |
| dc.contributor.author | Prakash, V | |
| dc.contributor.author | Iyer, V | |
| dc.contributor.author | Lapa, P | |
| dc.contributor.author | Isidoro, J | |
| dc.contributor.author | Pedroso de Lima, JM | |
| dc.contributor.author | Gambhir, SS | |
| dc.date.accessioned | 2016-05-06T16:27:38Z | |
| dc.date.available | 2016-05-06T16:27:38Z | |
| dc.date.issued | 2013-02 | |
| dc.description.abstract | (18)F-FDG PET/CT is used in a variety of cancers, but because of variable rates of glucose metabolism, not all cancers are reliably identified. (18)F(-) PET/CT allows for the acquisition of highly sensitive and specific images of the skeleton. We prospectively evaluated combined (18)F(-)/(18)F-FDG as a single PET/CT examination for evaluation of cancer patients and compared it with separate (18)F(-) PET/CT and (18)F-FDG PET/CT scans. METHODS: One hundred fifteen participants with cancer were prospectively enrolled in an international multicenter trial evaluating (18)F(-) PET/CT, (18)F-FDG PET/CT, and combined (18)F(-)/(18)F-FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. RESULTS: (18)F(-)/(18)F-FDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of (18)F-FDG PET/CT. In 19 participants, skeletal disease was more extensive on (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT than on (18)F-FDG PET/CT. In another 29 participants, (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT showed osseous metastases where (18)F-FDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. CONCLUSION: This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials. | pt_PT |
| dc.identifier.citation | J Nucl Med. 2013 Feb;54(2):176-83. | pt_PT |
| dc.identifier.doi | 10.2967/jnumed.112.108803 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1887 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Neoplasias/cintigrafia | pt_PT |
| dc.subject | Tomografia Computorizada | pt_PT |
| dc.subject | Tomografia por Emissão de Positrões | pt_PT |
| dc.subject | Fluordesoxiglucose F18 | pt_PT |
| dc.title | Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trial | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |