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Long-term survival in a patient with brain metastases of papillary thyroid carcinoma

dc.contributor.authorGuelho, D
dc.contributor.authorRibeiro, C
dc.contributor.authorMelo, M
dc.contributor.authorCarrilho, F
dc.date.accessioned2017-08-31T15:50:33Z
dc.date.available2017-08-31T15:50:33Z
dc.date.issued2016-03-09
dc.description.abstractWe present the case of a 43-year-old woman who underwent total thyroidectomy with bilateral lymphadenectomy for a papillary thyroid carcinoma (PTC), solid variant (T4bN1bMx), with V600E BRAF mutation. After ablative therapy, she presented undetectable thyroglobulin (Tg) but progressively increasing anti-Tg antibodies (TgAbs). During follow-up, nodal, lung and brain metastases were identified. She was submitted to surgical excision of lung lesions, radiosurgery of brain metastases and five radioiodine treatments. The latest brain MRI showed no lesions, pulmonary CT showed stable micronodules and there was progressive reduction in TgAbs. This is a peculiar case of a PTC with lung and brain metastatic lesions detected through TgAbs. Initial histological and molecular study suggested a more aggressive clinical behaviour, which was eventually confirmed. Although PTC brain metastases are extremely rare and present poor prognosis, our patient presented a good response to treatment and longer survival than usually reported for similar cases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Case Rep. 2016 Mar 9;2016. pii: bcr2015213824pt_PT
dc.identifier.doi10.1136/bcr-2015-213824pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2085
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectNeoplasias Encefálicaspt_PT
dc.subjectNeoplasias da Tiróidept_PT
dc.subjectCarcinomapt_PT
dc.titleLong-term survival in a patient with brain metastases of papillary thyroid carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagebcr2015213824pt_PT
oaire.citation.volume2016pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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