Publication
Valor prognóstico das proteínas p53, C-erB-2 E Ki67 no carcinoma do ovário
| dc.contributor.author | Frutuoso, C | |
| dc.contributor.author | Silva, MR | |
| dc.contributor.author | Amaral, N | |
| dc.contributor.author | Martins, MI | |
| dc.contributor.author | Oliveira, CF | |
| dc.contributor.author | Oliveira, HM | |
| dc.date.accessioned | 2008-12-03T16:22:27Z | |
| dc.date.available | 2008-12-03T16:22:27Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 67 expression by immunohistochemistry. The results were: age 5.4 +/- 15(22-88); 66% with normal physical activity; 48.2% with residual disease < 2 cm; initial stage--42% and advanced stage--58%. Age, performance status, residual disease and stage were correlated with 2 and 5 years survival. Positive immunostaining: p53--87%, C-erb B-2--51% and Ki67--100%. P53 and C-erb B-2 were associated with residual disease and stage; patients with no C-erbB-2 staining had a significantly better survival. A direct and significant correlation was found between p53 and Ki67 and between C-erb B-2 and p53. We conclude that these markers have a high expression in ovarian carcinoma and p53 and C-er B-2 correlate with stage and residual disease. Although C-erb B-2 was associated with better survival, it was not found to be an independent prognostic factor. | en |
| dc.identifier.citation | Acta Med Port. 2001 May-Jun;14(3):277-83 | en |
| dc.identifier.uri | http://hdl.handle.net/10400.4/263 | |
| dc.language.iso | por | en |
| dc.publisher | Centro Editor Livreiro da Ordem dos Médicos | en |
| dc.subject | Gene ERBB-2 | en |
| dc.subject | Neoplasias do Ovário | en |
| dc.subject | Antigénio ki-67 | en |
| dc.subject | Proteína Supressora de Tumor p53 | en |
| dc.title | Valor prognóstico das proteínas p53, C-erB-2 E Ki67 no carcinoma do ovário | en |
| dc.title.alternative | Prognosis value of p53, C-erB-2 and Ki67 proteins in ovarian carcinoma | en |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | |
| rcaap.type | article | en |