Repository logo
 
Publication

Oxaliplatin toxicity presenting as a liver nodule - case report

dc.contributor.authorAlexandrino, H
dc.contributor.authorOliveira, D
dc.contributor.authorCipriano, MA
dc.contributor.authorFerreira, L
dc.contributor.authorTralhão, JG
dc.contributor.authorCastro e Sousa, F
dc.date.accessioned2016-12-15T14:59:54Z
dc.date.available2016-12-15T14:59:54Z
dc.date.issued2015-04-10
dc.description.abstractBACKGROUND: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. CASE PRESENTATION: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. CONCLUSION: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Cancer. 2015 Apr 10;15:247.pt_PT
dc.identifier.doi10.1186/s12885-015-1247-4pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2007
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAnti-Neoplásicospt_PT
dc.subjectHepatopatia Veno-Oclusivapt_PT
dc.subjectBiopsiapt_PT
dc.subjectQuimioterapia Adjuvantept_PT
dc.subjectNeoplasias Colorrectaispt_PT
dc.subjectHepatic Veno-Occlusive Diseasept_PT
dc.titleOxaliplatin toxicity presenting as a liver nodule - case reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage247pt_PT
oaire.citation.volume15pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
16535.pdf
Size:
1.27 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: