Publication
Treatment of tumour recurrence after resection of hepatocellular carcinoma. Analysis of 97 consecutive patients
| dc.contributor.author | Tralhão, JG | |
| dc.contributor.author | Dagher, I | |
| dc.contributor.author | Lino, T | |
| dc.contributor.author | Roudié, J | |
| dc.contributor.author | Franco, D | |
| dc.date.accessioned | 2013-10-29T11:22:02Z | |
| dc.date.available | 2013-10-29T11:22:02Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | OBJECTIVE: To evaluate the long-term results of aggressive treatment of HCC recurrence. METHODS: Two hundred and nine consecutive patients underwent hepatic resection for HCC in our hospital. Tumour recurrence was diagnosed in 97 (51%) of the 190 patients with curative resection. Sixteen underwent hepatic resection: two right hepatectomies, one three-segmentectomy, one left hepatectomy, five two-segmentectomies, six segmental resections and one subsegmentectomy. Two patients with metastasis in the spine were submitted to a vertebral body resection. Twenty-five patients were treated with percutaneous ethanol injection or intra-arterial chemoembolization. Fifty-four patients with a poor performance status and liver function or multiple extra hepatic recurrences did not receive any treatment. RESULTS: There were no operative deaths. The postoperative mortality rate was 5.5% (one patient). The cumulative overall survival after the second resection was respectively 89%, 46% and 31% at 1, 3 and 5 years. There was a significant difference in survival between patients treated with repeat resection and those submitted to a non-surgical or conservative treatment (p<0.0001). There were no differences in operative deaths, postoperative mortality and morbidity between the first and second hepatic resection. CONCLUSIONS: Aggressive management with combined resection or loco regional therapy for intrahepatic recurrence and resection of isolated extra-hepatic recurrence may offer long-term survival in selected patients. Second liver resection for recurrence of HCC can be safely performed. | por |
| dc.identifier.citation | Eur J Surg Oncol. 2007;33(6):746-51. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1585 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.subject | Carcinoma Hepatocelular | por |
| dc.subject | Recidiva Local de Neoplasia | por |
| dc.subject | Hepatectomia | por |
| dc.title | Treatment of tumour recurrence after resection of hepatocellular carcinoma. Analysis of 97 consecutive patients | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |