Publication
Prognostic value of CA125 in advanced heart failure patients
| dc.contributor.author | Monteiro, S | |
| dc.contributor.author | Franco, F | |
| dc.contributor.author | Costa, S | |
| dc.contributor.author | Monteiro, P | |
| dc.contributor.author | Vieira, H | |
| dc.contributor.author | Coelho, L | |
| dc.contributor.author | Oliveira, L | |
| dc.contributor.author | Providência, LA | |
| dc.date.accessioned | 2009-05-20T14:00:57Z | |
| dc.date.available | 2009-05-20T14:00:57Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | INTRODUCTION: Serum levels of CA125 are often high in advanced heart failure (AHF) patients. AIM: To determine the predictive value of CA125 in forecasting the occurrence of death or cardiac transplantation in an AHF population. METHODS: 88 AHF patients referred for heart transplantation were divided into 2 groups based on CA125 levels: normal (CA125<38 U/mL) and elevated (>/=38 U/mL). Events (death or heart transplant) were monitored over a period of 13+/-7 months after CA125 determination. RESULTS: Patients with elevated CA125 (n=65) had significantly lower blood pressure, body mass index, serum sodium and peak exercise oxygen consumption, while B-type natriuretic peptide levels were significantly higher. The combined primary endpoint (death or heart transplant) rate was 39.4% and 62.3% in normal and elevated CA125 groups, respectively (p=0.029). Multivariate regression analysis showed that CA125 and sodium levels were the only independent predictors of the combined endpoint. CONCLUSION: In AHF patients, plasma CA125 was an effective prognostic marker. Its determination may contribute to better risk stratification in this population. | en |
| dc.identifier.citation | Int J Cardiol. 2009 Mar 11. | en |
| dc.identifier.uri | http://hdl.handle.net/10400.4/504 | |
| dc.language.iso | eng | en |
| dc.publisher | Elsevier | en |
| dc.rights.uri | openAccess | en |
| dc.subject | Antigénio CA-125 | en |
| dc.subject | Insuficiência Cardíaca | en |
| dc.title | Prognostic value of CA125 in advanced heart failure patients | en |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.type | article | en |